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However, with increasing rates of primary malignant melanoma, it is likely that the incidence of metastasis to rare sites, such as the endometrium, is also likely to increase. For those women with metastatic disease confined to the uterus, total abdominal hysterectomy +\/-bilateral\u2009salpingo-oophorectomy improved prognosis considerably. Newer<jats:italic>BRAF<\/jats:italic>molecular testing and targeted adjuvant therapy may also significantly improve prognosis in addition to surgical resection and should be considered.<\/jats:p>","DOI":"10.1136\/bcr-2018-224435","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T11:36:39Z","timestamp":1527680199000},"page":"bcr-2018-224435","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Endometrial metastasis of primary malignant melanoma of the brain"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-2457","authenticated-orcid":false,"given":"Jessica","family":"Little","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Braniff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"2025042703443286000_2018.may29_1.bcr-2018-224435.1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/1793-5482.151508","article-title":"Primary intracranial malignant melanoma: a rare casewith review of literature","volume":"10","author":"Suranagi","year":"2015","journal-title":"Asian J Neurosurg"},{"key":"2025042703443286000_2018.may29_1.bcr-2018-224435.2","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.3.5.569"},{"key":"2025042703443286000_2018.may29_1.bcr-2018-224435.3","first-page":"534","article-title":"Uterine metastasen malignant melanoma","volume":"123","author":"Glaubitz","year":"1992","journal-title":"Gerbutsh u Frauenheilk"},{"key":"2025042703443286000_2018.may29_1.bcr-2018-224435.4","unstructured":"Vora NL . 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