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A temporal artery biopsy was performed, which confirmed a healing large vessel vasculitis, possibly giant cell arteritis. He has responded very well to therapy. We must better appreciate the limitations of positron emission tomography in investigating a fever of unknown origin. The case also encourages awareness of autoimmune disorders as the leading category of causative diseases for this in older age groups.<\/jats:p>","DOI":"10.1136\/bcr-2018-224540","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T14:01:01Z","timestamp":1537365661000},"page":"bcr-2018-224540","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Positron emission tomography and reframing vasculitis as a spectrum of disease when investigating a patient with a fever of unknown origin"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-6181","authenticated-orcid":false,"given":"Farah","family":"Shahi","sequence":"first","affiliation":[{"name":"Hull and East Yorkshire Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anda","family":"Samson","sequence":"additional","affiliation":[{"name":"Hull and East Yorkshire Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A124"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s15010-009-8437-4","article-title":"Cutaneous vasculitis associated with fluoroquinolones","volume":"37","author":"Maunz","year":"2009","journal-title":"Infection"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.3","first-page":"e900","article-title":"Leukocytoclastic vasculitis with systemic involvement associated with ciprofloxacin therapy: case report and review of the literature","volume":"8","author":"Morgado","year":"2016","journal-title":"Cureus"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl554"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003971","article-title":"Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study","volume":"3","author":"Naito","year":"2013","journal-title":"BMJ Open"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/498174","article-title":"An unusual presentation of giant cell arteritis","volume":"2012","author":"Prabhavalkar","year":"2012","journal-title":"Case Rep Med"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.7","doi-asserted-by":"crossref","first-page":"687608","DOI":"10.1155\/2014\/687608","article-title":"The role of 18F-FDG PET\/CT in large-vessel vasculitis: appropriateness of current classification criteria?","volume":"2014","author":"Balink","year":"2014","journal-title":"Biomed Res Int"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.8","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100380"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.5.545"},{"issue":"5-6","key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00508-016-1159-6","article-title":"Recent trends in the distribution of causative diseases of fever of unknown origin","volume":"129","author":"Shang","year":"2017","journal-title":"Wien Klin Wochenschr"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.11","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000004146","article-title":"Positron emission tomography and computed tomography angiography for the diagnosis of giant cell arteritis: a real-life prospective study","volume":"95","author":"Lariviere","year":"2016","journal-title":"Medicine"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/574248","article-title":"Giant cell arteritis: a systematic review of the qualitative and semiquantitative methods to assess vasculitis with 18F-fluorodeoxyglucose positron emission tomography","volume":"2014","author":"Puppo","year":"2014","journal-title":"Biomed Res Int"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.13","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200081"},{"key":"2025082722240955000_2018.sep19_1.bcr-2018-224540.14","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1097\/01.smj.0000242334.80269.cd","article-title":"Giant cell arteritis mimicking multiple myeloma; 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