{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:55:06Z","timestamp":1756385706486,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,6,11]]},"abstract":"<jats:p>A 25-year-old male patient presented with complaints of blurred vision in both eyes since 2 years. The patient was a known case of nephrotic syndrome with dyslipidaemia for which he was on diuretics and lipid-lowering agents for 3 years. On examination, his visual acuity was 6\/9 in both eyes with cloudy cornea and arcus juvenilis. Fundus examination was within normal limits. On systemic work-up, his lipid profile was deranged with increased serum total cholesterol, very low density lipoprotein, low density lipoprotein and triglyceride. The serum high density lipoprotein was decreased. Renal function test revealed elevated serum creatinine with significant proteinuria. Renal biopsy was suggestive of dense deposit disease on immunofluorescence and transmission electron microscopy. Ocular manifestation of dense deposit disease is characterised by retinal drusen, pigmentary atrophy, choroidal neovascular membrane and atypical serous retinopathy. To the best of our knowledge, anterior segment changes in dense deposit disease has not been reported. This is the first case reporting cloudy cornea with arcus juvenilis in a case of dense deposit disease.<\/jats:p>","DOI":"10.1136\/bcr-2018-224545","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T13:50:00Z","timestamp":1530107400000},"page":"bcr-2018-224545","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Cloudy Cornea with Arcus Juvenilis in a Case of Dense Deposit Disease"],"prefix":"10.1136","volume":"2018","author":[{"given":"Pranita","family":"Sahay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishan","family":"Pandya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prafulla Kumar","family":"Maharana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/13816810.2015.1101777","article-title":"Retinal disease in the C3 glomerulopathies and the risk of impaired vision","volume":"37","author":"Savige","year":"2016","journal-title":"Ophthalmic Genet"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.2","doi-asserted-by":"crossref","first-page":"985-9","DOI":"10.1038\/sj.eye.6701697","article-title":"Retinal changes associated with type 2 glomerulonephritis","volume":"19","author":"McAvoy","year":"2005","journal-title":"Eye"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.3","doi-asserted-by":"crossref","first-page":"e3.1","DOI":"10.1016\/S0272-6386(03)00665-6","article-title":"Visual impairment caused by retinal abnormalities in mesangiocapillary (membranoproliferative) glomerulonephritis type II (\u201cdense deposit disease\u201d)","volume":"42","author":"Colville","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.sjopt.2016.11.005","article-title":"Multimodal imaging of membranoproliferative glomerulonephritis type II","volume":"30","author":"Cebeci","year":"2016","journal-title":"Saudi J Ophthalmol"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12886-017-0602-4","article-title":"Multimodal imaging of retinal pigment epithelial detachments in patients with C3 glomerulopathy: case report and review of the literature","volume":"17","author":"Kheir","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/ICB.0000000000000164","article-title":"Shedding light on fundus drusen associated with membranoproliferative glomerulonephritis: breaking stereotypes of types I, II, and III","volume":"10","author":"Dalvin","year":"2016","journal-title":"Retin Cases Brief Rep"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3928\/23258160-20141118-20","article-title":"High-speed ultrahigh-resolution OCT of Bruch\u2019s membrane in membranoproliferative glomerulonephritis type 2","volume":"45","author":"Adhi","year":"2014","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.8","first-page":"25","article-title":"Corneal opacifications in a low high density lipoprotein syndrome: suspicion of fish eye disease: a case report","volume":"282","author":"De Smedt","year":"2001","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.9","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010078"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.08.002"},{"key":"2025042705190311000_2018.jun27_1.bcr-2018-224545.11","unstructured":"Cruz Corchado J , Smith RJ . Dense deposit disease\/membranoproliferative glomerulonephritis type II.. In: Adam MP , Ardinger HH , Pagon RA , eds. GeneReviews\u00ae. 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