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Clinical course, serological examination, and radiological findings were consistent with localised hypocomplemental vasculitis caused by delayed hypersensitivity reaction. Immunosuppressive treatments using prednisolone successfully improved her symptoms. After a washout period for immunosuppressant, skin reaction test was performed and revealed polyglycolic-polylactic acid, coating material of the coil, positive for delayed allergic reaction. Given the increased frequency of endovascular treatment for unruptured aneurysms, even such a rare complication should be recognised and treated properly to avoid neurological sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2018-224569","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T07:45:31Z","timestamp":1529739931000},"page":"bcr-2018-224569","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Delayed leucoencephalopathy after coil embolisation of unruptured cerebral aneurysm"],"prefix":"10.1136","volume":"2018","author":[{"given":"Yoshihisa","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Cerebrovascular Medicine, St. Mary Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-2949","authenticated-orcid":false,"given":"Ichiro","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Strokology, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,23]]},"reference":[{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.wneu.2010.03.026","article-title":"Abnormal white matter changes after cerebral aneurysm treatment with polyglycolic-polylactic acid coils","volume":"74","author":"Skolarus","year":"2010","journal-title":"World Neurosurg"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0550"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.3","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0690"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.5.916"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.5","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/6\/1074"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.6","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1643"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.8","first-page":"252","article-title":"MR findings of cortical blindness following cerebral angiography: is this entity related to posterior reversible leukoencephalopathy?","volume":"25","author":"Saigal","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.9","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2176\/nmc.44.416","article-title":"Cortical blindness during coil embolization of an unruptured intracranial aneurysm--case report","volume":"44","author":"Shinoda","year":"2004","journal-title":"Neurol Med Chir"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.10","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0858"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.5692\/clinicalneurol.53.518","article-title":"[A case of posterior reversible encephalopathy syndrome associated with coil embolization of a basilar apex aneurysm]","volume":"53","author":"Naito","year":"2013","journal-title":"Rinsho Shinkeigaku"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.12","first-page":"1886","article-title":"Foreign bodies in small arteries after use of an infusion microcatheter","volume":"18","author":"Barnwell","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.13","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3976"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.14","first-page":"28","article-title":"Neurological changes with abnormal brain reactivity following coiling of cerebral aneurysm. possible reactivity to endovascular devices and material?","volume":"8","author":"Grewal","year":"2015","journal-title":"J Vasc Interv Neurol"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.15","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4415"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.16","doi-asserted-by":"publisher","DOI":"10.1177\/1591019915609171"},{"key":"2025082722541770000_2018.jun23_1.bcr-2018-224569.17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.carpath.2017.06.004","article-title":"Polymer coating embolism from intravascular medical devices - 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