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The outcome was favourable in most cases with antifungal therapy and either thoracocentesis or surgical resection. We also identified 40 cases of opportunistic infections, most commonly aspergillosis, cryptococcosis and <jats:italic>Pneumocystis jirovecii<\/jats:italic> pneumonia, in patients treated with ibrutinib. <jats:italic>In vitro<\/jats:italic> studies indicate Bruton tyrosine kinase inhibition impairs phagocyte function and offer a mechanism for the apparent association between ibrutinib and invasive fungal infections.<\/jats:p>","DOI":"10.1136\/bcr-2018-224786","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T12:32:44Z","timestamp":1531917164000},"page":"bcr-2018-224786","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Cryptococcus neoformans<\/i> empyema in a patient receiving ibrutinib for diffuse large B-cell lymphoma and a review of the literature"],"prefix":"10.1136","volume":"2018","author":[{"given":"Christopher 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