{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:26:07Z","timestamp":1760909167087,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,9,5]]},"abstract":"<jats:p>Sarcomatoid carcinoma is a rare tumour composed of intermingled malignant epithelial and mesenchymal cells, and it has been reported in various organs including the liver. Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver primary tumour. Here, we report a case of an elderly man who was admitted to our hospital after head trauma. He performed a head CT that diagnosed cerebral metastasis. On abdominal CT, he presented a 10\u00d78\u00d79\u2009cm-sized hypodense liver mass in the VII and VIII segments, with peripheral enhancement. Histological and immunohistochemical examination of the tumour showed a malignant neoplasm with both carcinomatous and sarcomatous components and positive expression of cytokeratin and vimentin antibodies. The patient was diagnosed with intrahepatic sarcomatoid CCC at an advanced stage and died 45\u2009days after the diagnosis. We emphasise the importance of immunohistochemistry which may provide a clue to proper diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2018-225017","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T23:58:15Z","timestamp":1537574295000},"page":"bcr-2018-225017","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Intrahepatic sarcomatoid cholangiocarcinoma"],"prefix":"10.1136","volume":"2018","author":[{"given":"Sara","family":"Sintra","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Costa","sequence":"additional","affiliation":[{"name":"Radiology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Filipe","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9lia","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/701476","article-title":"Intrahepatic sarcomatoid cholangiocarcinoma","volume":"2010","author":"Malhotra","year":"2010","journal-title":"J Oncol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00535-003-1203-y","article-title":"Intrahepatic sarcomatoid cholangiocarcinoma","volume":"38","author":"Kaibori","year":"2003","journal-title":"J Gastroenterol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.3","unstructured":"Nakanuma Y , Leong AS-Y , Sripa B , et al . World Health Organisation Classification of Tumours. Intrahepatic cholangiocarcinoma. In: Hamilton SR , Aaltonen LA , eds. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press, 2000:173\u201380."},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3350\/cmh.2014.20.3.313","article-title":"Sarcomatoid hepatocellular carcinoma with mixed osteoclast-like giant cells and chondroid differentiation","volume":"20","author":"Lee","year":"2014","journal-title":"Clin Mol Hepatol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.5","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-3-320"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.6","first-page":"599","article-title":"Intrahepatic sarcomatoid cholangiocarcinoma: clinical analysis of seven cases during a 15-year period","volume":"31","author":"Tsou","year":"2008","journal-title":"Chang Gung Med J"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3350\/cmh.2015.21.3.309","article-title":"Sarcomatoid cholangiocarcinoma with osteoclast-like giant cells associated with hepatolithiasis: A case report","volume":"21","author":"Kim","year":"2015","journal-title":"Clin Mol Hepatol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.8","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s10147-013-0586-x","article-title":"Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a review of the literature","volume":"19","author":"Watanabe","year":"2014","journal-title":"Int J Clin Oncol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.9","first-page":"51","article-title":"Sarcomatoid change in intrahepatic cholangiocarcinoma","volume":"8","author":"Albrechtsen","year":"2013","journal-title":"Sanamed"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1102\/1470-7330.2012.0036","article-title":"CT and MRI findings of sarcomatoid cholangiocarcinoma","volume":"12","author":"Bilgin","year":"2012","journal-title":"Cancer Imaging"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF02367798","article-title":"cholangiocarcinoma isarcomatous","volume":"30","author":"Imazu","year":"1995","journal-title":"J Gastroenterol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000335883","article-title":"Intrahepatic cholangiocarcinoma with sarcomatous changes","volume":"6","author":"Inoue","year":"2012","journal-title":"Case Rep Gastroenterol"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930915)72:6<1872::AID-CNCR2820720614>3.0.CO;2-N"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.14","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/BF02482354","article-title":"Intrahepatic cholangiocarcinoma with extensive sarcomatous change: report of a case","volume":"29","author":"Matsuo","year":"1999","journal-title":"Surg Today"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.14701\/kjhbps.2012.16.2.70","article-title":"Huge subcapsular hematoma caused by intrahepatic sarcomatoid cholangiocarcinoma","volume":"16","author":"Jung","year":"2012","journal-title":"Korean J Hepatobiliary Pancreat Surg"},{"key":"2025082722244658000_2018.sep21_1.bcr-2018-225017.16","first-page":"277","article-title":"Primary liver cancer in Japan. 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