{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:57:27Z","timestamp":1762001847652,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,19]]},"abstract":"<jats:p>Descending necrotising mediastinitis (DNM) is an uncommon clinical entity which may arise secondary to primary odontogenic or neck infection in susceptible patients. Infection may spread contiguously via the alar or \u2019danger' space, a potential anatomical space posterior to the true retropharyngeal space.<jats:sup>1<\/jats:sup> Spread of infection to the mediastinum almost always necessitates urgent cardiothoracic surgical intervention.<jats:sup>2\u20134<\/jats:sup> This case report describes a male patient whose clinical deterioration following the diagnosis of submandibular abscess was investigated with CT imaging of the chest, where a diagnosis of DNM was made. Diagnosis was confirmed following surgical intervention and aspiration of pus from the mediastinum.<\/jats:p>","DOI":"10.1136\/bcr-2018-225019","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T07:36:28Z","timestamp":1527665788000},"page":"bcr-2018-225019","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Taking heed of the \u2018danger space\u2019: acute descending necrotising mediastinitis secondary to primary odontogenic infection"],"prefix":"10.1136","volume":"2018","author":[{"given":"Rose","family":"Mark","sequence":"first","affiliation":[{"name":"Radiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swithin","family":"Song","sequence":"additional","affiliation":[{"name":"Radiology, Royal Perth Hospital, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Mark","sequence":"additional","affiliation":[{"name":"Radiology, Fiona Stanley Hospital, Murdoch, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082804450761000_2018.may29_1.bcr-2018-225019.1","DOI":"10.1097\/SLA.0b013e3181c1b0d1"},{"key":"2025082804450761000_2018.may29_1.bcr-2018-225019.2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ams2.56","article-title":"Descending necrotizing mediastinitis: 5 years of published data in Japan","volume":"2","author":"Sumi","year":"2015","journal-title":"Acute Med Surg"},{"key":"2025082804450761000_2018.may29_1.bcr-2018-225019.3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF03217934","article-title":"Guideline of surgical management based on diffusion of descending necrotizing mediastinitis","volume":"47","author":"Endo","year":"1999","journal-title":"Jpn J Thorac Cardiovasc Surg"},{"key":"2025082804450761000_2018.may29_1.bcr-2018-225019.4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00405-006-0174-z","article-title":"Descending necrotising mediastinitis: a safe treatment algorithm","volume":"264","author":"De Freitas","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"doi-asserted-by":"publisher","key":"2025082804450761000_2018.may29_1.bcr-2018-225019.5","DOI":"10.1016\/j.joms.2011.05.007"},{"key":"2025082804450761000_2018.may29_1.bcr-2018-225019.6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcms.2010.10.001","article-title":"Descending necrotizing mediastinitis following dental extraction. 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