{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:39:38Z","timestamp":1758271178982,"version":"3.40.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,9,11]]},"abstract":"<jats:p>We present the first case of upper airway obstruction secondary to a retropharyngeal Gardner-associated fibroma (GAF). A 16-month-old infant presented with a 3-month history of worsening dyspnoea and apnoeic episodes. Examination revealed stridor and left-sided retropharyngeal asymmetry. MRI demonstrated a mass in the retropharynx. Tracheostomy and pharyngeal biopsy under anaesthesia were performed, and histology confirmed a diagnosis of GAF. The mass was excised using a transcervical approach, and postoperative recovery was unremarkable. GAF is associated with Gardner\u2019s syndrome (GS) and familial adenomatous polyposis (FAP), both of which are associated with multiple colonic polyps and increased risk of colorectal malignancy. Subsequent testing for an APC mutation seen in GS and FAP was negative in our patient. The details of this unusual presentation of a rare disease are given in addition to a review of the literature.<\/jats:p>","DOI":"10.1136\/bcr-2018-225079","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T06:51:04Z","timestamp":1538203864000},"page":"bcr-2018-225079","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Gardener-associated fibroma: an unusual cause of upper airway obstruction"],"prefix":"10.1136","volume":"2018","author":[{"given":"Rohan Sebastian","family":"Pinto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.annpat.2009.09.003","article-title":"Fibroblastic and myofibroblastic tumors of the head and neck","volume":"29","author":"Sa\u00efji","year":"2009","journal-title":"Ann Pathol"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213348.65014.0a"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.3","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1097\/MPH.0000000000000493","article-title":"Gardner Fibroma: clinical and histopathologic implications of germline APC Mutation Association","volume":"38","author":"Dahl","year":"2016","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0036-1582443","article-title":"Neonatal gardner fibroma leads to detection of familial adenomatous polyposis: two case reports","volume":"4","author":"Sch\u00e4fer","year":"2016","journal-title":"Eur J Pediatr Surg rep"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200105000-00012"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.epsc.2017.02.011","article-title":"Management of a posterior mediastinal Gardner fibroma causing critical airway stenosis in a resource limited setting","volume":"20","author":"Clouthier","year":"2017","journal-title":"J Pediatr Surg Case Rep"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.anorl.2016.05.007","article-title":"Gardner\u2019s syndrome presenting with a fibromatous tumour of the parotid","volume":"133","author":"Guignard","year":"2016","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.8","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/0016-5085(93)90164-8","article-title":"Nasopharyngeal angiofibroma in patients with familial adenomatous polyposis","volume":"105","author":"Giardiello","year":"1993","journal-title":"Gastroenterology"},{"key":"2025042706252831000_2018.sep28_1.bcr-2018-225079.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1045"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:25:34Z","timestamp":1745760334000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":9,"alternative-id":["10.1136\/bcr-2018-225079"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225079","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,9,28]]}}}