{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:02:25Z","timestamp":1763114545918,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,11]]},"abstract":"<jats:p>We report the case of a 23-year-old woman who presented with bloody diarrhoea and multiple syncopal events. While the initial diagnosis clinically appeared to be inflammatory bowel disease, she was found to have a portal vein thrombosis (PVT) on MR cholangiopancreatography and acute intestinal ischaemia on colonic biopsy. The aetiology of this patient\u2019s PVT is attributed to her acquired prothrombotic state from an estrogen-containing contraceptive pill in conjunction with regular tobacco use. Extensive mesenteric venous thrombosis from an acute PVT has been shown to cause intestinal ischaemia, likely from venous obstruction and reflexive arterial constriction; however, the diagnosis is often delayed until surgery or autopsy. Our case report highlights this patient\u2019s clinical presentation, workup and treatment, as part of a review for the risk factors and guidelines recommendations for management of an acute PVT.<\/jats:p>","DOI":"10.1136\/bcr-2018-225135","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T09:55:16Z","timestamp":1533376516000},"page":"bcr-2018-225135","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Acute intestinal ischaemia from a portal vein thrombosis in a young female smoker on an oral contraceptive"],"prefix":"10.1136","volume":"2018","author":[{"given":"John","family":"Hunninghake","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care, US Army Brooke Army Medical Center, Fort Sam Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-6762","authenticated-orcid":false,"given":"Brian Patrick","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, US Army Brooke Army Medical Center, Fort Sam Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care, US Army Brooke Army Medical Center, Fort Sam Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gancayco","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, US Army Brooke Army Medical Center, Fort Sam Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,4]]},"reference":[{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.1","DOI":"10.1007\/s11739-008-0128-0"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.2","DOI":"10.3748\/wjg.v12.i13.2115"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.3","DOI":"10.1002\/hep.23259"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.4","DOI":"10.1002\/hep.22772"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.5","DOI":"10.1097\/00000478-199504000-00007"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.6","DOI":"10.1056\/NEJMra010076"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.7","DOI":"10.1111\/j.1365-2036.2004.01903.x"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.8","DOI":"10.1002\/ajh.21059"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.9","DOI":"10.1007\/s10024-004-7079-x"},{"key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.10","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1186\/1757-1626-2-7416","article-title":"Massive intestinal ischemia, a rare complication of oral contraceptive-induced mesenteric venous thrombosis: a case report and review of literature","volume":"2","author":"Efremidou","year":"2009","journal-title":"Cases J"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.11","DOI":"10.1002\/hep.510310213"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.12","DOI":"10.1002\/hep.510310307"},{"doi-asserted-by":"publisher","key":"2025082623291496000_2018.aug03_2.bcr-2018-225135.13","DOI":"10.1136\/gut.49.5.720"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:29:21Z","timestamp":1756276161000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,4]]},"references-count":13,"alternative-id":["10.1136\/bcr-2018-225135"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225135","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,8,4]]}}}