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No osteosclerotic lesions on appendicular bones were present. Pericardiocentesis temporarily controlled tamponade and corticoid therapy temporarily abated exophthalmos. Pericardiectomy definitively resolved tamponade. Histological examination of pericardial tissue was conclusive of Erdheim-Chester disease. Exophthalmos responded to pegylated interferon-alpha-2a. Facial bone pain disappeared after zoledronic acid and interferon treatment. During interferon therapy, the patient suffered from a severe generalised desquamative exanthema that slowly resolved after discontinuing interferon. Diabetes insipidus remains controlled with desmopressin.<\/jats:p>","DOI":"10.1136\/bcr-2018-225224","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:45:14Z","timestamp":1539823514000},"page":"bcr-2018-225224","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease"],"prefix":"10.1136","volume":"2018","author":[{"given":"Jaume","family":"Monmany","sequence":"first","affiliation":[{"name":"Medicina Interna, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Granell","sequence":"additional","affiliation":[{"name":"Diagn\u00f2stic per la Imatge, Hospital de la Santa Creu i Sant Pau, Barcelona, 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