{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:23:30Z","timestamp":1757780610037,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,9]]},"abstract":"<jats:p>A 45-year-old woman presented to the emergency department with jaundice of 2\u2009weeks\u2019 duration. This was associated with mahogany seed extract (Skyfruit supplement) consumption for 6\u2009months prior to admission. Examination was normal apart from scleral icterus and grade 2 encephalopathy. Liver function tests showed a hepatocellular pattern of derangement: alanine transaminase, 1267\u2009U\/L (10\u201336); aspartatetransaminase, 1255\u2009U\/L (10\u201330); alkaline phosphatase, 124\u2009U\/L (22\u2013104); bilirubin, 258\u2009\u00b5mol\/L (3\u201321) with a prolonged prothrombin time of 16.8\u2009s (9.2\u201311.0). Viral hepatitis work-up was largely unremarkable and liver biopsy showed moderate inflammatory infiltrates (mostly lymphocytic with scattered eosinophils) in the periportal region and lobule with bridging necrosis, favouring drug-induced liver injury. Withdrawal of the drug resulted in normalisation of liver function.<\/jats:p>","DOI":"10.1136\/bcr-2018-225382","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T13:17:08Z","timestamp":1532956628000},"page":"bcr-2018-225382","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Liver failure associated with mahogany seed extract consumption"],"prefix":"10.1136","volume":"2018","author":[{"given":"Valerie","family":"Yeap","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence Jin Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Loh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajneesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240002"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.3","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20204"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01461.x"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.18433\/J36G6X","article-title":"Hepatotoxic botanicals\u2014an evidence-based systematic review","volume":"16","author":"Abdualmjid","year":"2013","journal-title":"J Pharm Pharm Sci"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.6","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.3390\/molecules180910465","article-title":"Biological activities and phytochemicals of Swietenia macrophylla King","volume":"18","author":"Moghadamtousi","year":"2013","journal-title":"Molecules"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.7","first-page":"271","article-title":"Anti-inflammatory, antimutagenicity, and antitumor-promoting activities of mahogany seeds, Swietenia macrophylla (Meliacea)","volume":"125","author":"Guevara","year":"1996","journal-title":"Philipp J Sci"},{"key":"2025042705435763000_2018.jul27_1.bcr-2018-225382.8","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.131"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:44:04Z","timestamp":1745757844000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":8,"alternative-id":["10.1136\/bcr-2018-225382"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225382","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}