{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:30:29Z","timestamp":1771993829505,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>A 66-year-old woman with chronic myeloid leukaemia in nilotinib-induced remission was diagnosed with amaurosis fugax, caused by carotid stenosis. Serum cholesterol was 316\u2009mg\/dL (Low-Density Lipoprotein (LDL) cholesterol 213\u2009mg\/dL). Nilotinib was discontinued and replaced by interferon. Antiplatelet therapy and atorvastatin 40\u2009mg\/day were prescribed. Muscle pain and elevation of serum creatine kinase (CK) occurred; thus, atorvastatin was replaced by ezetimibe. Afterwards, muscle pain subsided and CK reverted to normal, but 2 years later serum cholesterol was still elevated at 218\u2009mg\/dL with LDL cholesterol 126\u2009mg\/dL. Simvastatin 5\u2009mg\/day was then started, but again muscle pain occurred and CK rose to 267\u2009U\/L. Simvastatin was stopped and serum cholesterol climbed to 252\u2009mg\/dL. Creatine was prescribed and simvastatin was reintroduced. Two months later, cholesterol was 171\u2009mg\/dL, CK was 72\u2009U\/L and there was no muscle pain. This case supports the view that creatine may prevent statin-induced myopathy.<\/jats:p>","DOI":"10.1136\/bcr-2018-225395","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T15:15:08Z","timestamp":1535382908000},"page":"bcr-2018-225395","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Statin-induced myopathy prevented by creatine administration"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-2200","authenticated-orcid":false,"given":"Maurizio","family":"Balestrino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Adriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70058-4"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq165"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.3","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.2015.15629","article-title":"Statins for prevention of cardiovascular disease in adults: Evidence report and systematic review for the us preventive services task force","volume":"316","author":"Chou","year":"2016","journal-title":"JAMA"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1001\/jama.2017.6753","article-title":"Treatment of Cholesterol in 2017","volume":"318","author":"Krumholz","year":"2017","journal-title":"JAMA"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.5","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/S0140-6736(16)31357-5","article-title":"Interpretation of the evidence for the efficacy and safety of statin therapy","volume":"388","author":"Collins","year":"2016","journal-title":"Lancet"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv043"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.7","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-5686-z"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.7326\/0003-4819-153-10-201011160-00024","article-title":"Creatine supplementation prevents statin-induced muscle toxicity","volume":"153","author":"Shewmon","year":"2010","journal-title":"Ann Intern Med"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.2.201"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.07.026"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.11","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.clml.2017.07.006","article-title":"Cardiovascular Events After Exposure to Nilotinib in Chronic Myeloid Leukemia: Long-term Follow-up","volume":"17","author":"Aghel","year":"2017","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.7205\/MILMED.172.3.312","article-title":"The effect and safety of short-term creatine supplementation on performance of push-ups","volume":"172","author":"Armentano","year":"2007","journal-title":"Mil Med"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.13","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-10-26"},{"key":"2025042706042552000_2018.aug27_1.bcr-2018-225395.14","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00726-015-2165-0","article-title":"Creatine for neuroprotection in neurodegenerative disease: end of story?","volume":"48","author":"Bender","year":"2016","journal-title":"Amino Acids"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:04:32Z","timestamp":1745759072000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":14,"alternative-id":["10.1136\/bcr-2018-225395"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225395","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}