{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:19:21Z","timestamp":1773908361062,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,9]]},"abstract":"<jats:p>A 43-year-old Japanese man with a low haemoglobin level of 1.3\u2009g\/dL and multiorgan dysfunction syndrome (MODS) was admitted to our hospital. He was diagnosed with folate deficiency, which was initially attributed to his malnutrition. He was transfused with several units of packed red blood cells and treated with folate, thiamine and vitamin B<jats:sub>12<\/jats:sub>supplements; he showed a prompt haematological response and recovery from MODS. However, 3 weeks after the initial recovery, he had a relapse of pancytopenia and developed high-grade fever along with rapidly enlarging, generalised lymphadenopathy. Bone marrow biopsy revealed hemophagocytosis, and lymph node biopsy revealed peripheral T-cell lymphoma, not otherwise specified. Folate supplementation may have promoted lymphoma progression.<\/jats:p>","DOI":"10.1136\/bcr-2018-225482","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T12:45:45Z","timestamp":1533559545000},"page":"bcr-2018-225482","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Can folate replacement induce lymphoma progression?"],"prefix":"10.1136","volume":"2018","author":[{"given":"Nobuhiro","family":"Ariyoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Koyamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.1","doi-asserted-by":"crossref","unstructured":"Clarke V , Weston-Smith S . Severe folate-deficiency pancytopenia. BMJ Case Rep 2010.","DOI":"10.1136\/bcr.03.2010.2851"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90771-4"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.19.1.29"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.4","first-page":"314","article-title":"Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects","volume":"57","author":"Kim","year":"1999","journal-title":"Nutr Rev"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.5","unstructured":"Antony AC , et al Megaloblastic anemias. In: Hoffman R , Benz EJ Jr , Silberstein LE , Heslop H , Weitz J , Anastasi J , . eds. Hematology: basic principles and practice. 6th edn: Saunders: Elsevier, 2013:473\u2013504."},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.3205"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.21.1.255"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60110-5"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084635","article-title":"Folic acid supplementation promotes mammary tumor progression in a rat model","volume":"9","author":"Deghan Manshadi","year":"2014","journal-title":"PLoS One"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.10","doi-asserted-by":"publisher","DOI":"10.1038\/srep12044"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/pcan.2014.16","article-title":"Folate intake and the risk of prostate cancer: a systematic review and meta-analysis","volume":"17","author":"Tio","year":"2014","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.12","first-page":"26","article-title":"Thiamine deficiency and delirium","volume":"10","author":"Osiezagha","year":"2013","journal-title":"Innov Clin Neurosci"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.13","unstructured":"Thiamine BRF. In: Shils ME , Shike M , Caballero B , Cousins RJ , Ross AC , et al . Modern nutrition in health and disease. 10th edn. Philadelphia: Lippincott Williams & Wilkins, 2006:426\u201333."},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.14","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3002-1-16"},{"key":"2025042705490465000_2018.aug06_1.bcr-2018-225482.15","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1046\/j.1432-1327.2001.02329.x","article-title":"The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study","volume":"268","author":"Com\u00edn-Anduix","year":"2001","journal-title":"Eur J Biochem"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:49:15Z","timestamp":1745758155000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":15,"alternative-id":["10.1136\/bcr-2018-225482"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225482","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]}}}