{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:10:01Z","timestamp":1756375801505,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,15]]},"abstract":"<jats:p>Mitotane is a cytostatic antineoplastic agent that is used in the treatment of adrenocortical carcinoma and Cushing\u2019s syndrome. The commonly reported side effects associated with mitotane are anorexia, nausea, vomiting, diarrhoea, decreased memory, rash, gynaecomastia, arthralgias and leucopenia. We present a case of a 68-year-old female who developed gradual dyspnoea concurrent with the use of mitotane for the treatment of adrenocortical carcinoma. To the best of our knowledge and literate review, this is the first reported case of dyspnoea associated with the use of this medication. The purpose of this case report is to raise awareness about this uncommon adverse effect of mitotane that may have gone unrecognised on postmarketing surveillance because of under-reporting, lack of case follow-up or other comorbidities masking shortness of breath.<\/jats:p>","DOI":"10.1136\/bcr-2018-225490","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T08:35:17Z","timestamp":1535790917000},"page":"bcr-2018-225490","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Mitotane-induced dyspnoea: an unusual side effect"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-0097","authenticated-orcid":false,"given":"Ali U","family":"Farooq","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Charleston Area Medical Center, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Amjad","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases, Mercy Medical Center, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanureet","family":"Kochar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Charleston Area Medical Center, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Charleston Area Medical Center, Charleston, South Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23886"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2639"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.10.008"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004263221705"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.5","doi-asserted-by":"crossref","unstructured":"Fassnacht M , Allolio B . Epidemiology of adrenocortical carcinoma. In: Hammer G , Else T , eds. Adrenocortical Carcinoma. 1st edn. New York,\u00a0NY: Springer, 2010:23\u20139.","DOI":"10.1007\/978-0-387-77236-3_3"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200966"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.7","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.8","first-page":"386","article-title":"Mitotane for adrenocortical carcinoma treatment","volume":"6","author":"Hahner","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.9","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90033-6"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010915)92:6<1385::AID-CNCR1461>3.0.CO;2-2"},{"key":"2025082802531582000_2018.sep01_1.bcr-2018-225490.11","doi-asserted-by":"publisher","DOI":"10.1136\/adc.34.174.178"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:53:23Z","timestamp":1756374803000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":11,"alternative-id":["10.1136\/bcr-2018-225490"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225490","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}