{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:06Z","timestamp":1756374006129,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,1]]},"abstract":"<jats:p>The thyroid is a rare site for metastasis, occurring in 0.1% of colorectal cases. A 46-year-old man with rectal adenocarcinoma developed an enlarging anterior neck mass and increasing carcinoembryonic antigen 2\u2009years after curative intent treatment. Imaging showed aggressive features with invasion of the larynx, trachea and oesophagus, suspicious for anaplastic thyroid carcinoma. The patient underwent tumour debulking with neck dissection and tracheostomy. Final histopathological review revealed metastatic adenocarcinoma from a colorectal primary. Despite chemotherapy, the patient eventually succumbed to disease progression and complications of his illness. This case demonstrates that recognising rare sites of metastasis may help clinicians effectively institute earlier intervention.<\/jats:p>","DOI":"10.1136\/bcr-2018-225549","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:40:28Z","timestamp":1534243228000},"page":"bcr-2018-225549","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Thyroid metastasis from rectal adenocarcinoma"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-1197","authenticated-orcid":false,"given":"Madelaine Amurao","family":"Amante","sequence":"first","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irisyl Orolfo","family":"Real","sequence":"additional","affiliation":[{"name":"Section of Medical Oncology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gherald","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.1","unstructured":"Globocan.iarc.fr. Fact Sheets by Cancer [Internet]. 2017. http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx (cited 21 Aug 2017)."},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.06.012"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt591"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.4","doi-asserted-by":"crossref","first-page":"38658-66","DOI":"10.18632\/oncotarget.6130","article-title":"Pattern of distant metastases in colorectal cancer: a SEER based study","volume":"6","author":"Qiu","year":"2015","journal-title":"Oncotarget"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196004000-00015"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.6","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196408000-00001"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.7","first-page":"37","article-title":"Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients","volume":"122","author":"Lam","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196205\/06)15:3<557::AID-CNCR2820150315>3.0.CO;2-H"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2265.2007.02773.x","article-title":"Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience","volume":"66","author":"Papi","year":"2007","journal-title":"Clin Endocrinol"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.012"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02206.x"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.12","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.ejca.2005.11.042","article-title":"Thyroid metastases from colorectal cancer: the Institut Gustave Roussy experience","volume":"42","author":"Li\u00e8vre","year":"2006","journal-title":"Eur J Cancer"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.13","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000259625.74256.01"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.14","first-page":"1","article-title":"Metastasis of colorectal adenocarcinoma to the thyroid: a case report and review of the literature","volume":"2012","author":"Goatman","year":"2012","journal-title":"Case Rep Surg"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.15","first-page":"3","article-title":"A metastasis of colorectal cancer to the thyroid gland which has also papillary thyroid cancer: a case report","volume":"38","author":"Yalcin","year":"2008","journal-title":"Turkish Journal of Cancer"},{"key":"2025082802253208000_2018.aug14_1.bcr-2018-225549.16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/thy.2006.0114","article-title":"Metastasis of rectal adenocarcinoma: an unusual cause of rapidly enlarging thyroid mass with myxedema","volume":"17","author":"Ishay","year":"2007","journal-title":"Thyroid"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:25:37Z","timestamp":1756373137000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,14]]},"references-count":16,"alternative-id":["10.1136\/bcr-2018-225549"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225549","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,8,14]]}}}