{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:32:06Z","timestamp":1763551926476,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,22]]},"abstract":"<jats:p>Lipodystrophy syndromes are frequently associated with marked degree of insulin resistance and lipoatrophic diabetes. Although acquired generalised lipodystrophy (AGL) has been known to be associated with various autoimmune disorders, type 1 diabetes mellitus (T1DM) is very rarely reported to occur with AGL. Combination of AGL and T1DM can lead to a totally different phenotype with very difficult-to-treat diabetes and progressive complications of both the conditions. We report a case of AGL with T1DM with poor diabetes control despite high doses of insulin, metformin and pioglitazone. Our case further progressed to develop complication of retroperitoneal fibrosis, not hitherto reported with AGL.<\/jats:p>","DOI":"10.1136\/bcr-2018-225553","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T03:24:36Z","timestamp":1533266676000},"page":"bcr-2018-225553","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Acquired generalised lipodystrophy and type 1 diabetes mellitus in a child: a rare and implacable association"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-2142","authenticated-orcid":false,"given":"Rakesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Post Graduate Institude of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-1704","authenticated-orcid":false,"given":"Rakesh Kumar","family":"Pilania","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Post Graduate Institude of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anmol","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devi","family":"Dayal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Post Graduate Institude of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200303000-00007"},{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1856"},{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/jc.2016-2271","article-title":"Clinical features and management of non-HIV-related lipodystrophy in children: a systematic review","volume":"102","author":"Gupta","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.4","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1210\/jc.2016-2466","article-title":"The diagnosis and management of lipodystrophy syndromes: a multi-society practice guideline","volume":"101","author":"Brown","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.5","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1210\/jc.2016-3628","article-title":"Effects of metreleptin in pediatric patients with lipodystrophy","volume":"102","author":"Brown","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.6","first-page":"383","article-title":"Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis","volume":"114","author":"Parums","year":"1990","journal-title":"Arch Pathol Lab Med"},{"issue":"Suppl 5","key":"2025082804052968000_2018.aug02_1.bcr-2018-225553.7","first-page":"S213","article-title":"Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report","volume":"128 Suppl 5","author":"Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute","year":"2011","journal-title":"Pediatrics"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:05:36Z","timestamp":1756379136000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":7,"alternative-id":["10.1136\/bcr-2018-225553"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225553","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,8,3]]}}}