{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:20:13Z","timestamp":1773436813282,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,9,5]]},"abstract":"<jats:p>Giant fornix syndrome (GFS) was first described as a cause for a relapsing mucopurulent conjunctivitis. Predominantly elderly patients have enlarged superior fornices from superior aponeurosis dehiscence that permits the accumulation of protein coagulum that is colonised by bacteria. Established treatment includes the use of intensive topical antibiotic and corticosteroid. We describe a case of a 98-year-old woman with GFS who did not respond to several weeks of intensive (two hourly) treatment with topical prednisolone 1% drops and chloramphenicol. Subsequent additional regular sweeping of the fornices with cotton buds and topical medication did not improve her symptoms but which resolved with manual coagulum debridement and application of 10% povidone-iodine. This treatment offers an effective treatment option of GFS cases, which do not respond to intensive topical corticosteroids and chloramphenicol.<\/jats:p>","DOI":"10.1136\/bcr-2018-225555","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T05:44:31Z","timestamp":1539409471000},"page":"bcr-2018-225555","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Management of giant fornix syndrome with irrigation with povidone-iodine"],"prefix":"10.1136","volume":"2018","author":[{"given":"Rushmia","family":"Karim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niraj","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Tuft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.01.037"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/ICO.0b013e3181eeb703","article-title":"Subconjunctival injections and povidone-iodine washings for the treatment of giant fornix syndrome","volume":"30","author":"Taylor","year":"2011","journal-title":"Cornea"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/IOP.0000000000000727","article-title":"Fornix Reduction for Treatment of Giant Fornix Syndrome","volume":"32","author":"Vahdani","year":"2016","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/IOP.0b013e3182264440","article-title":"Giant fornix syndrome: a case series","volume":"28","author":"Turaka","year":"2012","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.5","first-page":"30","article-title":"The ocular application of povidone-iodine","volume":"16","author":"Isenberg","year":"2003","journal-title":"Community Eye Health"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.6","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030584025"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1590\/S0004-27492003000300005","article-title":"Corneal and conjunctival toxicity of povidone-iodine eye drops","volume":"66","author":"Santos","year":"2003","journal-title":"Arquivos Brasileiros De Oftalmoolgia"},{"key":"2025042706310554000_2018.oct12_1.bcr-2018-225555.8","unstructured":"Sekhon B . Iodine: A support against infections and emerging as an antibiotic. 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