{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:13:54Z","timestamp":1760300034983,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,6,17]]},"abstract":"<jats:p>The number of released free cholesterol crystal emboli (fCCE) and their role during percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) have not been documented yet. Furthermore, fCCE manifesting in the coronary lumen following plaque rupture has been historically overlooked owing to the standard tissue preparation for light microscopy which uses ethanol as a dehydrating agent that can dissolve fCCE, leaving behind empty tissue. In this case report, we evaluated fCCE released during PCI for ACS and their relationship with myocardial injury and coronary artery obstruction on the H&amp;E-stained sections by using polarised light microscopy. To our knowledge, there has been no mention of the visibility of fCCE on H&amp;E-stained frozen polarised sections before.<\/jats:p>","DOI":"10.1136\/bcr-2018-225558","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T01:16:57Z","timestamp":1531358217000},"page":"bcr-2018-225558","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Visible-free cholesterol crystal emboli adjacent to microinfarcts in myocardial capillaries and arterioles on H&amp;E-stained frozen sections of an autopsied patient"],"prefix":"10.1136","volume":"2018","author":[{"given":"Chikao","family":"Yutani","sequence":"first","affiliation":[{"name":"Department of Pathology, Amagasaki Central Hospital, Amagasaki, Japan"},{"name":"Department of Pathology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-5264","authenticated-orcid":false,"given":"Sei","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Osaka Gyoumeikan Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Center, Osaka Gyoumeikan Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x05vm640ra"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886465"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.7555\/JBR.31.20160100","article-title":"Cholesterol crystal embolization following plaque rupture: a systemic disease with unusual features","volume":"31","author":"Ghanem","year":"2017","journal-title":"J Biomed Res"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.539"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.5","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.amjcard.2017.07.075","article-title":"Frequency of cholesterol crystals in culprit coronary artery aspirate during acute myocardial infarction and their relation to inflammation and myocardial injury","volume":"120","author":"Abela","year":"2017","journal-title":"Am J Cardiol"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2007.10.006"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.7","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22560"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.8","first-page":"244","article-title":"Coronary artery embolism with special reference to invasive procedures as the source","volume":"5","author":"Yutani","year":"1992","journal-title":"Mod Pathol"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.9","first-page":"789","article-title":"Cerebro-spinal infarction caused by atheromatous emboli","volume":"35","author":"Yutani","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1231"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.11","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF01879595","article-title":"Experimentelle beitr\u00e4ge zur lehre von der embolie","volume":"25","author":"Panum","year":"1862","journal-title":"Virchows Archiv"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.12","first-page":"549","article-title":"Arterial occlusions produced by emboli from eroded aortic atheromatous plaques","volume":"21","author":"Flory","year":"1945","journal-title":"Am J Pathol"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1253\/circj.CJ-15-0126","article-title":"Early detection of vulnerable atherosclerotic plaque for risk reduction of acute aortic rupture and thromboemboli and atheroemboli using non-obstructive angioscopy","volume":"79","author":"Komatsu","year":"2015","journal-title":"Circ J"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv484"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12350-017-0826-y","article-title":"PET\/CTA detection of muscle inflammation related to cholesterol crystal emboli without arterial obstruction","volume":"25","author":"Pervaiz","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.16","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.43.607"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/01.STR.11.2.184","article-title":"Cholesterol crystal embolization in rat brain: a model for atheroembolic cerebral infarction","volume":"11","author":"Steiner","year":"1980","journal-title":"Stroke"},{"key":"2025082703590528000_2018.jul10_1.bcr-2018-225558.18","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.496737"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:59:13Z","timestamp":1756292353000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":18,"alternative-id":["10.1136\/bcr-2018-225558"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225558","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}