{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:36:38Z","timestamp":1774524998886,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,10,13]]},"abstract":"<jats:p>A 46-year-old previously healthy man presented with 1\u2009week of headache, nausea, vomiting and dizziness. He was found to have cranial nerve deficits, his cerebrospinal fluid (CSF) demonstrated a lymphocytic pleocytosis and brain MRI suggested rhombencephalitis. Although Gram stains and cultures of his CSF did not identify a pathogen, <jats:italic>Listeria monocytogenes<\/jats:italic> DNA was detected by the FilmArray Meningitis\/Encephalitis panel within 2\u2009hours of performing a lumbar puncture. He was treated with ampicillin and gentamicin and had a near-complete recovery. This case highlights the importance of recognising <jats:italic>L. monocytogenes<\/jats:italic> infection as a cause of acute cranial nerve impairment with MRI findings suggestive of brainstem encephalitis. It also highlights the frequently atypical CSF profile and low yield of culture in <jats:italic>L. monocytogenes<\/jats:italic> rhombencephalitis and the value of multiplex PCR testing of CSF to rapidly identify this pathogen and permit targeted therapy.<\/jats:p>","DOI":"10.1136\/bcr-2018-225575","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T02:25:11Z","timestamp":1541730311000},"page":"bcr-2018-225575","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Rapid detection of <i>Listeria monocytogenes<\/i> rhombencephalitis in an immunocompetent patient by multiplexed PCR"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-6933","authenticated-orcid":false,"given":"Rocco J","family":"Richards","sequence":"first","affiliation":[{"name":"Infectious Diseases Service\/Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S","family":"Simon","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Douglas","family":"Phillips","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Lief","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S","family":"Satlin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical Center, NewYork-Presbyterian Hospital, New York City, New York, USA"},{"name":"Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, WeillCornell Medical Center, New York-Presbyterian Hospital, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.1","doi-asserted-by":"crossref","unstructured":"Lorber B . Listeria monocytogenes. In: Mandell GL , Bennett JE , Dolin R , eds. Principles and Practice of Infectious Diseases. 7th edn. Philadelphia, PA: Churchill Livingstone, 2010:2707\u201314.","DOI":"10.1016\/B978-0-443-06839-3.00207-1"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.2","first-page":"210","article-title":"Encephalomyelitis listeriaca apostematosa","volume":"87","author":"Eck","year":"1957","journal-title":"Schweiz Med Wochenschr"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.3","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.5.689"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318224b5af"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01957-16"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01159-16"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.7","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00730-16"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30521-7"},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.9","unstructured":"European Centre for Disease Prevention and Control. \u00a0EU case definitions. Food- and waterborne diseases and diseases of environmental origin: listeriosis. https:\/\/ecdc.europa.eu\/en\/infectious-diseases-public-health\/surveillance-and-disease-data\/eu-case-definitions (Accessed 22 Mar 2018)."},{"key":"2025082805315820000_2018.nov08_1.bcr-2018-225575.10","unstructured":"Centers for Disease Control and Prevention. National Notifiable Diseases Surveillance System (NNDSS): listeriosis. https:\/\/wwwn.cdc.gov\/nndss\/conditions\/listeriosis\/case-definition\/2000\/ (Accessed 21 Nov 2017)."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:32:06Z","timestamp":1756384326000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":10,"alternative-id":["10.1136\/bcr-2018-225575"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225575","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]}}}