{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:27Z","timestamp":1756339467957,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,28]]},"abstract":"<jats:p>Thrombocytopenia-associated multiple-organ failure (TAMOF) is an increasingly fatal phenomenon that may be associated with sepsis. TAMOF results from immune dysregulation and impaired activity of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif, member 13. Early recognition of this premorbid condition and specific management results in a significantly improved outcome. Herein, we report the presentation and management of a 2-year-old child with TAMOF who was successfully treated with plasma exchange and recovered without long-term sequelae.<\/jats:p>","DOI":"10.1136\/bcr-2018-225594","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T11:28:48Z","timestamp":1535369328000},"page":"bcr-2018-225594","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Thrombocytopenia-associated multiple-organ failure (TAMOF): recognition and management"],"prefix":"10.1136","volume":"2018","author":[{"given":"Musaab","family":"Ramsi","sequence":"first","affiliation":[{"name":"Paediatric Critical Care Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyaa Saeed","family":"Al Ali","sequence":"additional","affiliation":[{"name":"Paediatric Critical Care Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.1","first-page":"245","article-title":"Thrombocytopenia in sepsis: a predictor of mortality in the intensive care unit","volume":"34","author":"Lee","year":"1993","journal-title":"Singapore Med J"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000257468.75474.D4"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.3","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00005"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.4","doi-asserted-by":"publisher","DOI":"10.1186\/cc5064"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.5","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1097\/PCC.0000000000001052","article-title":"Pathophysiology of pediatric multiple organ dysfunction syndrome","volume":"18","author":"Carcillo","year":"2017","journal-title":"Pediatr Crit Care Med"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00130478-200107000-00001","article-title":"Microvascular thrombosis in pediatric multiple organ failure: is it a therapeutic target?","volume":"2","author":"Nguyen","year":"2001","journal-title":"Pediatr Crit Care Med"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.7","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318186aa49"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.8","doi-asserted-by":"crossref","first-page":"e354","DOI":"10.1097\/PCC.0000000000000227","article-title":"Use of therapeutic plasma exchange in children with thrombocytopenia-associated multiple organ failure in the Turkish thrombocytopenia-associated multiple organ failure network","volume":"15","author":"Sevketoglu","year":"2014","journal-title":"Pediatr Crit Care Med"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.9","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jpedsurg.2013.02.061","article-title":"A case series of the successful use of ECMO, continuous renal replacement therapy, and plasma exchange for thrombocytopenia-associated multiple organ failure","volume":"48","author":"Bridges","year":"2013","journal-title":"J Pediatr Surg"},{"key":"2025082707312349000_2018.aug27_1.bcr-2018-225594.10","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.pcl.2017.06.007","article-title":"Rationale for adjunctive therapies for pediatric sepsis induced multiple organ failure","volume":"64","author":"Podd","year":"2017","journal-title":"Pediatr Clin North Am"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:31:29Z","timestamp":1756305089000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":10,"alternative-id":["10.1136\/bcr-2018-225594"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225594","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}