{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:51:32Z","timestamp":1786917092054,"version":"build-2736575974"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,11,15]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>A 49-year-old Caucasian woman presented with subacute headache and right eye pain associated with scotoma, blurred vision and photophobia. MRI was suggestive of optic neuritis of the right optic nerve and she was treated with steroids. Due to persistent symptoms, a lumbar puncture was performed and cerebrospinal fluid analysis was positive for venereal disease research laboratory and rapid plasma reagin titres. On further history, she recalled experiencing an illness associated with diffuse rash, likely secondary syphilis, 1\u20132 months prior. She tested negative for HIV. She was treated with intravenous penicillin for 2\u2009weeks following which she experienced improvement in symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2018-225635","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T15:09:18Z","timestamp":1545491358000},"page":"e225635","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Optic neuritis caused by the re-emerging great masquerader"],"prefix":"10.1136","volume":"11","author":[{"given":"Nathanial S","family":"Nolan","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Internal Medicine-Pediatrics, University of Missouri Columbia School of Medicine, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madihah A","family":"Hepburn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Missouri Columbia School of Medicine, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elkeeb","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Missouri Columbia, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariharan","family":"Regunath","sequence":"additional","affiliation":[{"name":"Department of Medicine, Divisions of Pulmonary, Critical Care Medicine and Infectious Diseases, Columbia, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"2025082703114691000_11.1.e225635.1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/WCO.0000000000000414","article-title":"Optic neuritis: the eye as a window to the brain","volume":"30","author":"Jenkins","year":"2017","journal-title":"Curr Opin Neurol"},{"key":"2025082703114691000_11.1.e225635.2","doi-asserted-by":"publisher","DOI":"10.1177\/1756285611398702"},{"key":"2025082703114691000_11.1.e225635.3","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1097\/WNO.0000000000000180","article-title":"Atypical optic neuritis","volume":"34","author":"Warren","year":"2014","journal-title":"J Neuroophthalmol"},{"key":"2025082703114691000_11.1.e225635.4","first-page":"402","article-title":"Primary and secondary syphilis-United States, 2005-2013","volume":"63","author":"Patton","year":"2014","journal-title":"MMWR Morbidity and mortality weekly report"},{"key":"2025082703114691000_11.1.e225635.5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/01658107.2015.1134586","article-title":"Syphilitic optic neuropathy: re-emerging cases over a 2-year period","volume":"40","author":"Apinyawasisuk","year":"2016","journal-title":"Neuroophthalmology"},{"key":"2025082703114691000_11.1.e225635.6","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.15585\/mmwr.mm6543a2","article-title":"Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015","volume":"65","author":"Oliver","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025082703114691000_11.1.e225635.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc1000968"},{"key":"2025082703114691000_11.1.e225635.8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.994"},{"key":"2025082703114691000_11.1.e225635.9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1212\/WNL.46.2.368","article-title":"Cerebrospinal fluid in acute optic neuritis: experience of the optic neuritis treatment trial","volume":"46","author":"Rolak","year":"1996","journal-title":"Neurology"},{"key":"2025082703114691000_11.1.e225635.10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00415-013-7166-x","article-title":"Differential diagnoses to MS: experiences from an optic neuritis clinic","volume":"261","author":"Horwitz","year":"2014","journal-title":"J Neurol"},{"key":"2025082703114691000_11.1.e225635.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00501-3"},{"key":"2025082703114691000_11.1.e225635.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.012"},{"key":"2025082703114691000_11.1.e225635.13","first-page":"402","article-title":"Primary and secondary syphilis--United States, 2005-2013","volume":"63","author":"Patton","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025082703114691000_11.1.e225635.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03300500026022"},{"key":"2025082703114691000_11.1.e225635.15","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-197804000-00009"},{"key":"2025082703114691000_11.1.e225635.16","unstructured":"Syphilis LSA . et al In: Kasper D , Fauci A , Hauser S , Longo D , Jameson JL , Loscalzo J , . eds. Harrison\u2019s Principles of Internal Medicine . 19th edn. New York, NY: McGraw-Hill Education, 2015."},{"key":"2025082703114691000_11.1.e225635.17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-11-855"},{"key":"2025082703114691000_11.1.e225635.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707313370504"},{"key":"2025082703114691000_11.1.e225635.19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.29-49.2006"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:11:53Z","timestamp":1756289513000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,22]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bcr-2018-225635"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225635","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}