{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:36:12Z","timestamp":1787016972528,"version":"build-2736575974"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,10]]},"abstract":"<jats:p>\n                    <jats:italic>Atopobium vaginae<\/jats:italic>\n                    is an anaerobic gram-positive organism associated with genitourinary infections. Bacteraemia is rare, with only two cases reported in the literature. This case describes an 18-year-old type 1 diabetic, presenting with sepsis and haemoptysis, on a background of poor dental hygiene and recurrent hospital admissions. Blood cultures grew\n                    <jats:italic>A. vaginae<\/jats:italic>\n                    and echocardiogram revealed a large tricuspid valve lesion. Despite medical therapy, symptoms of pulmonary emboli continued and she therefore underwent surgical resection of the lesion. Histopathological findings were of a vegetation; culture of the lesion was negative but 16S ribosomal PCR was positive, detecting 16S rRNA of\n                    <jats:italic>A. vaginae<\/jats:italic>\n                    . The patient was treated with 4\u2009weeks of vancomycin and made a good recovery. To our knowledge, this represents the first report of infective endocarditis due to this organism. We also provide a review of the literature, including comparing published drug susceptibility data with consensus breakpoints for antimicrobial agents.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2018-225871","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T08:35:21Z","timestamp":1535790921000},"page":"bcr-2018-225871","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Infective endocarditis due to\n                    <i>Atopobium vaginae<\/i>\n                    : a rare association between genital infection and endocarditis of the tricuspid valve"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-3713","authenticated-orcid":false,"given":"Josephine","family":"Mansell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Gourtsoyannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Draz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaridh","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.01.010"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jocs.13600","article-title":"Tricuspid valve endocarditis in the era of the opioid epidemic","volume":"33","author":"Wallen","year":"2018","journal-title":"J Card Surg"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.3","first-page":"157","article-title":"Tricuspid valve endocarditis following septic abortion","volume":"34","author":"Vaidya","year":"1986","journal-title":"J Assoc Physicians India"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.4","first-page":"235","article-title":"Comparative sequence analyses of the 16S rRNA genes of lactobacillus minutus, lactobacillus rimae and streptococcus parvulus: proposal for the creation of a new genus atopobium","volume":"74","author":"Collins","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.5","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1099\/00207713-49-4-1573","article-title":"Characterization of a novel Atopobium isolate from the human vagina: description of Atopobium vaginae sp. nov","volume":"49 Pt 4","author":"Rodriguez Jovita","year":"1999","journal-title":"Int J Syst Bacteriol"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-1"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.7","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052285"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.8","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-010-0100-6"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2788-2790.2003"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.10","doi-asserted-by":"publisher","DOI":"10.3201\/eid1502.071399"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.11","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.065243-0"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01655-10"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.13","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00212-12"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.14","first-page":"647939","article-title":"Draft genome sequence of a metronidazole-susceptible atopobium vaginae isolate","volume":"3","author":"Schuyler","year":"2015","journal-title":"Genome Announc"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-51"},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.16","unstructured":"EUCAST. European committee on antimicrobial susceptibility testing breakpoint tables for interpretation of mics and zone diameters european committee on antimicrobial susceptibility testing breakpoint tables for interpretation of mics and zone diameters. 2017 http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_7.1_Breakpoint_Tables.pdf."},{"key":"2025042706083598000_2018.sep01_1.bcr-2018-225871.17","unstructured":"Hecht DW , Citron DM , Dzink-Fox J , et al . Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard. 8th Edition. Pennsylvani: Clinical and Laboratory Standards Institute, 2012."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:08:42Z","timestamp":1745744922000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":17,"alternative-id":["10.1136\/bcr-2018-225871"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225871","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}