{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:21:41Z","timestamp":1785248501823,"version":"3.55.0"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,12,24]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month history of irregular vaginal bleeding and suspicious cervix. Transvaginal ultrasound showed a 3\u00d73.8 cm cervical mass with a marked increase in the blood flow. MRI pelvis showed an exophytic tumour with left external iliac lymph node metastasis. Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high Ki67 proliferation index. A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was treated with chemotherapy and palliative radiotherapy but died 21 months after presenting. Neuroendocrine tumour of the uterine cervix is an extremely aggressive cancer with the late presentation\u2014the need for a more rigorous treatment protocol as well as potential screening methods could improve outcomes for these patients.<\/jats:p>","DOI":"10.1136\/bcr-2018-225880","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T12:59:29Z","timestamp":1547470769000},"page":"bcr-2018-225880","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Large cell neuroendocrine carcinoma of the uterine cervix"],"prefix":"10.1136","volume":"12","author":[{"given":"Amir","family":"Habeeb","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Habeeb","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Gillingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"2025082623591251000_12.1.bcr-2018-225880.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199708000-00004"},{"key":"2025082623591251000_12.1.bcr-2018-225880.2","first-page":"456","article-title":"Small Cell Carcinoma of the Uterine Cervix: a case report with emphasis on cytopathological findings","volume":"18","author":"Huang","year":"2006","journal-title":"Tzu Chi Med J"},{"key":"2025082623591251000_12.1.bcr-2018-225880.3","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ec124e"},{"key":"2025082623591251000_12.1.bcr-2018-225880.4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ygyno.2016.12.003","article-title":"Neuroendrocrine tumors of the uterine cervix: a therapeutic challenge for gynecologic oncologists","volume":"144","author":"Gadducci","year":"2017","journal-title":"Gynecol Oncol"},{"key":"2025082623591251000_12.1.bcr-2018-225880.5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981001)83:7<1391::AID-CNCR17>3.0.CO;2-#"},{"key":"2025082623591251000_12.1.bcr-2018-225880.6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.6.825"},{"key":"2025082623591251000_12.1.bcr-2018-225880.7","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6201"},{"key":"2025082623591251000_12.1.bcr-2018-225880.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(02)00150-6"},{"key":"2025082623591251000_12.1.bcr-2018-225880.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00003"},{"key":"2025082623591251000_12.1.bcr-2018-225880.10","first-page":"397","article-title":"The carcinoid syndrome and multiple hormone secretion associated with a carcinoid tumour of the uterine cervix. Case report","volume":"93","author":"Stockdale","year":"1986","journal-title":"Br J Obstet Gynaecol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-225880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:59:21Z","timestamp":1756277961000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-225880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,14]]},"published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1136\/bcr-2018-225880"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-225880","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}