{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:02:42Z","timestamp":1778659362896,"version":"3.51.4"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,12]]},"abstract":"<jats:p>A 49-year-old woman, known case of diffuse large B-cell lymphoma, presented with complaints of floater in both eyes since 3 days. On examination, visual acuity was 0.18 logMAR in both eyes. Indirect ophthalmoscopy revealed presence of vitreous clumps. Vitreous biopsy was done and the histopathological report suggested a diagnosis of ocular lymphoma. The patient was treated with weekly injections of intravitreal methotrexate in both eyes. The patient developed severe photophobia, watering, redness and diminution of vision in the both eyes 2\u2009days following the fifth dose of intravitreal methotrexate. Severe limbitis with annular corneal epitheliopathy and corneal haze was noted on slit-lamp examination. The patient was started on topical lubricants, antibiotic, ciclosporin, loteprednol, folinic acid and oral folic acid. Complete resolution was noted at 2-week follow-up. The patient, however, refused further injections and was kept on close follow-up to look for recurrence of the disease.<\/jats:p>","DOI":"10.1136\/bcr-2018-226005","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T11:38:11Z","timestamp":1535369891000},"page":"bcr-2018-226005","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Corneal epithelial toxicity with intravitreal methotrexate in a case of B-cell lymphoma with ocular involvement"],"prefix":"10.1136","volume":"2018","author":[{"given":"Pranita","family":"Sahay","sequence":"first","affiliation":[{"name":"Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prafulla Kumar","family":"Maharana","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreyas","family":"Temkar","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Chawla","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"2025082623414218000_2018.aug27_1.bcr-2018-226005.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01125-9"},{"key":"2025082623414218000_2018.aug27_1.bcr-2018-226005.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.127928"},{"key":"2025082623414218000_2018.aug27_1.bcr-2018-226005.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh088"},{"key":"2025082623414218000_2018.aug27_1.bcr-2018-226005.4","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903370755"},{"key":"2025082623414218000_2018.aug27_1.bcr-2018-226005.5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1097\/ICO.0b013e3182910106","article-title":"Toxic corneal epitheliopathy after intravitreal methotrexate and its treatment with oral folic acid","volume":"32","author":"Gorovoy","year":"2013","journal-title":"Cornea"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:41:48Z","timestamp":1756276908000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,27]]},"references-count":5,"alternative-id":["10.1136\/bcr-2018-226005"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226005","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,27]]}}}