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He subsequently underwent reinduction chemotherapy with aggressive intrathecal chemotherapy followed by posterior globe and whole brain radiation therapy. He is currently on his 26th month of treatment, in second remission, with complete resolution of leukaemic infiltrative optic neuropathy and facial paralysis. As more cases of this nature are reported, we will be able to determine the relevance of this distinct cytogenetic entity.<\/jats:p>","DOI":"10.1136\/bcr-2018-226006","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:16:28Z","timestamp":1534810588000},"page":"bcr-2018-226006","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Trisomy 5 as the sole chromosomal anomaly in acute lymphoblastic leukaemia"],"prefix":"10.1136","volume":"2018","author":[{"given":"Preeti Prerna M","family":"Vaswani","sequence":"first","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita E","family":"Dumagay","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"2025082703351465000_2018.aug20_1.bcr-2018-226006.1","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: a comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J"},{"key":"2025082703351465000_2018.aug20_1.bcr-2018-226006.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-0734.2002.00069.x"},{"key":"2025082703351465000_2018.aug20_1.bcr-2018-226006.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(00)00084-9"},{"key":"2025082703351465000_2018.aug20_1.bcr-2018-226006.4","unstructured":"Kaushansky K , Prchal JT , Press OW , eds. 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