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Histological and molecular analysis was consistent with the diagnosis of undifferentiated pleomorphic sarcoma with murine double minute 2 (<jats:italic>MDM2<\/jats:italic>) amplification. Given the overall grim prognosis, the patient chose to pursue comfort-based care. She died at home 9\u2009months after the initial diagnosis. Here, we provide an updated review of the literature for the classification of undifferentiated pleomorphic cardiac sarcoma and potential treatment modalities.<\/jats:p>","DOI":"10.1136\/bcr-2018-226073","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T01:04:23Z","timestamp":1538355863000},"page":"bcr-2018-226073","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Primary undifferentiated pleomorphic cardiac sarcoma with <i>MDM2<\/i> amplification presenting as acute left-sided heart failure"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-9370","authenticated-orcid":false,"given":"Richard","family":"Watson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Frye","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Trieu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-0206","authenticated-orcid":false,"given":"Michael X","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.078576"},{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.2","first-page":"74","article-title":"Primary tumor of the heart","volume":"39","author":"Straus","year":"1945","journal-title":"Arch Pathol"},{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970501)79:9<1809::AID-CNCR25>3.0.CO;2-0"},{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920115)69:2<387::AID-CNCR2820690219>3.0.CO;2-N"},{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89149-7"},{"key":"2025082623591931000_2018.sep29_1.bcr-2018-226073.6","unstructured":"Burke A , Veinot J , Loire R . 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