{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:18:57Z","timestamp":1784258337793,"version":"3.55.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,30]]},"abstract":"<jats:p>A 36-year-old male, soft contact lens wearer was referred by his primary ophthalmologist for corneal ulcer of the right eye (OD), which was persistent despite topical fluoroquinolone therapy for 1\u2009month. A ring-shaped infiltrate typically seen in Acanthamoeba infection was noted, and topical therapy with chlorhexidine and polyhexamethylene biguanide was initiated. However, the patient\u2019s condition deteriorated over the next several weeks; thus, diagnostic and therapeutic penetrating keratoplasty was performed. The postoperative immunohistochemical analysis suggested a diagnosis of herpes simplex virus (HSV) keratitis. The patient ultimately improved after initiation of oral valacyclovir following penetrating keratoplasty. We report a case of a commonly encountered clinical entity, HSV keratitis, with an atypical clinical presentation, masquerading as Acanthamoeba keratitis.<\/jats:p>","DOI":"10.1136\/bcr-2018-226100","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T17:56:02Z","timestamp":1537379762000},"page":"bcr-2018-226100","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-3900","authenticated-orcid":false,"given":"Rohan Bir","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Batta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.096230"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.15585\/mmwr.mm6532a2","article-title":"Contact lens-related corneal infections\u00a0\u2013 United States, 2005\u20132015","volume":"65","author":"Cope","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jtos.2015.01.002","article-title":"Acanthamoeba keratitis: clinical characteristics and management","volume":"13","author":"Jiang","year":"2015","journal-title":"Ocul Surf"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.009"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.04.001"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pop.2015.05.007","article-title":"Herpes zoster ophthalmicus","volume":"42","author":"Johnson","year":"2015","journal-title":"Prim Care"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700616"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/eye.1989.91","article-title":"Thiomersal keratoconjunctivitis, frequency, clinical spectrum and diagnosis","volume":"3","author":"Wilson-Holt","year":"1989","journal-title":"Eye"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.9","first-page":"784","article-title":"Immunopathogenesis of corneal inflammation in herpes simplex virus stromal keratitis: role of the polymorphonuclear leukocyte","volume":"20","author":"Meyers-Elliott","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025042706184022000_2018.sep19_1.bcr-2018-226100.10","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/00003226-200111000-00029","article-title":"Triple anterior stromal ring infiltrate associated with presumed HSV keratitis","volume":"20","author":"Pandit","year":"2001","journal-title":"Cornea"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:18:47Z","timestamp":1745759927000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":10,"alternative-id":["10.1136\/bcr-2018-226100"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226100","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]}}}