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We present in this paper a paediatric case of PBV anaphylaxis and of biphasic reaction that exemplifies the challenges involved in diagnosing and managing this rare but potentially life-threatening allergic reaction.<\/jats:p>","DOI":"10.1136\/bcr-2018-226191","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T07:08:54Z","timestamp":1548227334000},"page":"e226191","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Anaphylaxis to patent blue dye in a 17-year-old boy"],"prefix":"10.1136","volume":"12","author":[{"given":"M\u00e9lanie","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"McCusker","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Ben-Shoshan","sequence":"additional","affiliation":[{"name":"Division of Allergy Immunology and Dermatology, Department of Paediatrics, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"2025082711382017000_12.1.e226191.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.10.007"},{"key":"2025082711382017000_12.1.e226191.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02248.x"},{"key":"2025082711382017000_12.1.e226191.3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bjan.2014.02.017","article-title":"Allergic reaction to patent blue dye in breast surgery - case report","volume":"66","author":"Maranh\u00e3o","year":"2016","journal-title":"Braz J Anesthesiol"},{"key":"2025082711382017000_12.1.e226191.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.040"},{"key":"2025082711382017000_12.1.e226191.5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1445-2197.2012.06277.x","article-title":"Patent Blue V dye anaphylaxis: experience of Australian and New Zealand surgeons","volume":"84","author":"Wong","year":"2014","journal-title":"ANZ J Surg"},{"key":"2025082711382017000_12.1.e226191.6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/0310057X1103900221","article-title":"Anaphylaxis and other adverse reactions to blue dyes: a case series","volume":"39","author":"Howard","year":"2011","journal-title":"Anaesth Intensive Care"},{"key":"2025082711382017000_12.1.e226191.7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1398-9995.2009.02192.x","article-title":"Anaphylaxis to Patent Blue V. 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