{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:14:24Z","timestamp":1769130864146,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,10,31]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>A 39-year-old Caucasian woman, who has never smoked, presented a 16-year-duration chronic dry cough. She was prescribed by her general physician with corticosteroid and long-acting \u03b2-agonist inhalers assuming it was asthma, with mild symptomatic improvement. When cough got more persistent and associated with exertional dyspnoea and wheezing, a chest CT scan was performed, which showed multiple bilateral micronodular formations and diffuse mosaic lung pattern with air trapping. She was sent to our Respiratory Department and performed a bronchoalveolar lavage and cryobiopsy that were inconclusive. She underwent surgical lung biopsy with pathology revealing multiple foci of neuroendocrine cell hyperplasia and tumourlets associated with constrictive bronchiolitis, a histological pattern suggestive of diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH). DIPNECH is a rare and preinvasive disease. Presenting symptoms can be cough and breathlessness. At the time of writing, the patient is on octreotide with symptomatic improvement.<\/jats:p>","DOI":"10.1136\/bcr-2018-226203","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"e226203","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Diffuse idiopathic neuroendocrine cell hyperplasia as a rare cause of chronic cough"],"prefix":"10.1136","volume":"11","author":[{"given":"Paula In\u00eas","family":"Pedro","sequence":"first","affiliation":[{"name":"Pulmonology, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Can\u00e1rio","sequence":"additional","affiliation":[{"name":"Pulmonology, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lopes","sequence":"additional","affiliation":[{"name":"Pulmonology, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Garcia de Orta EPE, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"2025082703334816000_11.1.e226203.1","unstructured":"Gosney JR , Austin JHM , Jett J . Diffuse pulmonary neuroendocrine cell hyperplasia. In: Travis WD , Brambilla E , Burke AP , Marx A , Nicholson AG . eds. WHO classification of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2015:78\u20139."},{"key":"2025082703334816000_11.1.e226203.2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01954-2015"},{"key":"2025082703334816000_11.1.e226203.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210293271806"},{"key":"2025082703334816000_11.1.e226203.4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1053\/j.semdp.2015.08.002","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)","volume":"32","author":"Marchevsky","year":"2015","journal-title":"Semin Diagn Pathol"},{"key":"2025082703334816000_11.1.e226203.5","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.063065"},{"key":"2025082703334816000_11.1.e226203.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1685PP"},{"key":"2025082703334816000_11.1.e226203.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0711"},{"key":"2025082703334816000_11.1.e226203.8","doi-asserted-by":"crossref","first-page":"e0275","DOI":"10.1002\/rcr2.275","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by tranbronchoscopic cryoprobe biopsy technique","volume":"5","author":"Patel","year":"2017","journal-title":"Respirol Case Rep"},{"key":"2025082703334816000_11.1.e226203.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9754-2"},{"key":"2025082703334816000_11.1.e226203.10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.185.3.341a"},{"key":"2025082703334816000_11.1.e226203.11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.2.207"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bcr-2018-226203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:33:59Z","timestamp":1756290839000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,28]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bcr-2018-226203"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226203","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}