{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:29:08Z","timestamp":1761395348301,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,10,9]]},"abstract":"<jats:p>Sinonasal adenocarcinoma has traditionally been treated with surgery (craniofacial or endoscopic) and adjuvant radiotherapy. Two large series have demonstrated favourable 5-year survival using surgery with adjuvant topical chemotherapy applied repeatedly over several weeks. The authors describe a novel, transnasal application of topical 5-fluorouracil. However, complete coverage of the frontal region of the anterior skull base can be difficult to achieve with a purely transnasal approach in an outpatient setting. We present a novel adjunct method of delivering chemotherapeutic agents into this key area used in a 37-year-old man with T2N0M0 ethmoid adenocarcinoma. The procedure was well tolerated in an outpatient setting and remains disease free at 3 years postoperatively. We suggest that frontal trephination is a useful adjunct to aid accurate placement of adjuvant topical chemotherapeutic agents in the treatment of sinonasal adenocarcinoma.<\/jats:p>","DOI":"10.1136\/bcr-2018-226234","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T02:37:20Z","timestamp":1540435040000},"page":"bcr-2018-226234","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Trans-Frontal Five-Fluorouracil (TraFFF): a novel technique for the application of adjuvant topical chemotherapeutic agents in sinonasal adenocarcinoma"],"prefix":"10.1136","volume":"2018","author":[{"given":"Narinder","family":"Singh","sequence":"first","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-5083","authenticated-orcid":false,"given":"Eugene","family":"Wong","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnson","family":"Huang","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faruque","family":"Riffat","sequence":"additional","affiliation":[{"name":"Otolaryngology, Head and Neck Surgery, Westmead Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01790.x"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.2.141"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900120062010"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1017\/S0022215100140745","article-title":"Combined transfacial and neurosurgical approach to malignant tumours of the ethmoid sinus","volume":"112","author":"Salvan","year":"1998","journal-title":"J Laryngol Otol"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.5","first-page":"354","article-title":"Surgical outcomes of endoscopic management of adenocarcinoma of the sinonasal cavity","volume":"47","author":"Jardeleza","year":"2009","journal-title":"Rhinology"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.6","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3170"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2500\/105065899782102935","article-title":"The role of mini-trephination in the management of frontal sinusitis","volume":"13","author":"Gallagher","year":"1999","journal-title":"Am J Rhinol"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200101000-00024"},{"key":"2025082700465937000_2018.oct24_1.bcr-2018-226234.9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00015"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:47:09Z","timestamp":1756280829000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,24]]},"references-count":9,"alternative-id":["10.1136\/bcr-2018-226234"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226234","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,10,24]]}}}