{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:34:16Z","timestamp":1787682856757,"version":"build-2784847793"},"reference-count":10,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,11,5]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Fewer than 90 cases of granular cell tumour (GCT) of the biliary tract have been reported, including only five cases of multiple GCTs. We present the unusual case of a 40-year-old woman with multifocal GCTs affecting the intrahepatic biliary tree, which were initially suspected to be hepatic multiple metastases from a malignancy of unknown origin. The surgical specimen consisted of a hepatic segment in which five whitish nodular lesions were observed. On microscopic examination, nodular lesions were found in the portal tracts; these were composed of large polygonal cells with abundant highly granular cytoplasm. The nuclei were small and centrally located. The tumour cells tested diffusely positive for CD68-PGM1, S100 protein and \u03b1-inhibin, so a diagnosis of multifocal GCT of the biliary tree was made. Three years later, the patient is still alive and a MRI has shown no changes.<\/jats:p>","DOI":"10.1136\/bcr-2018-226352","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"e226352","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Multifocal granular cell tumour of the biliary tree"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-5425","authenticated-orcid":false,"given":"Felip","family":"Vilardell","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology, Hospital Universitari Arnau de Vilanova and Institut de Recerca Biom\u00e8dica de Lleida, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pardina","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitari Arnau de Vilanova, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Juan","family":"Olsina","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Matias-Guiu","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"2025082800550101000_11.1.e226352.1","first-page":"398","article-title":"Granular cell myoblastoma of the common bile duct; a report case with autopsy findings","volume":"54","author":"Coggins","year":"1952","journal-title":"Arch Pathol Lab Med"},{"key":"2025082800550101000_11.1.e226352.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.12.007"},{"key":"2025082800550101000_11.1.e226352.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02078314"},{"key":"2025082800550101000_11.1.e226352.4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/1097-0142(195307)6:4<790::AID-CNCR2820060421>3.0.CO;2-O","article-title":"An early granular-cell myoblastoma confined within a small peripheral myelinated nerve","volume":"6","author":"Bangle","year":"1953","journal-title":"Cancer"},{"key":"2025082800550101000_11.1.e226352.5","unstructured":"Elder D , Elenitsas R , Johnson B , et al . 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Report of a case","volume":"106","author":"Aisner","year":"1982","journal-title":"Arch Pathol Lab Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bcr-2018-226352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:55:09Z","timestamp":1756367709000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,28]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bcr-2018-226352"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226352","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}