{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:42:45Z","timestamp":1784191365178,"version":"3.55.0"},"reference-count":6,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,10,22]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Acute lymphoblastic leukaemia (ALL) is one of the the most common malignancies of childhood and can occasionally present as acute airway obstruction. We present the unusual case of a 1-year-old boy who was referred to our Paediatric Otolaryngology (ENT) clinic with a recurrent history of croup. This is the first reported case of localised ALL presenting as a subglottic mass in a paediatric patient. It highlights the need to have a broader differential diagnosis in children presenting with \u2018recurrent croup\u2019 including extramedullary presentation of leukaemia and to have a low threshold for performing endoscopy in such cases.<\/jats:p>","DOI":"10.1136\/bcr-2018-226364","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"e226364","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Subglottic acute lymphoblastic leukaemia"],"prefix":"10.1136","volume":"11","author":[{"given":"Shilpa","family":"Ojha","sequence":"first","affiliation":[{"name":"Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Gaskin","sequence":"additional","affiliation":[{"name":"ENT, University Hospitals Bristol NHS Foundation Trust, Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Saunders","sequence":"additional","affiliation":[{"name":"University Hospitals Bristol NHS Foundation Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"2025082804053098000_11.1.e226364.1","unstructured":"Draper GJ , Stiller CA , O\u2019Connor CM , et al . The geographical epidemiology of childhood leukaemia and non-Hodgkin lymphomas in Great Britain, 1966-83. OPCS studies on medical and population subjects, no 53. London: OPCS, 1991."},{"key":"2025082804053098000_11.1.e226364.2","first-page":"53","article-title":"A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukaemia (ALL)","volume":"14","author":"Redaelli","year":"2005","journal-title":"Eur J Cancer Care"},{"key":"2025082804053098000_11.1.e226364.3","unstructured":"Acute lymphoblastic leukaemia (ALL) in children and young adults up to 16 years. Retrieve from www.bloodwise.org.uk"},{"key":"2025082804053098000_11.1.e226364.4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/000348940111000702","article-title":"Diagnosis of Recurrent Intermittent Airway Obstruction (\u201cRecurrent Croup\u201d) in Children","volume":"110","author":"Farmer","year":"2001","journal-title":"Ann Otol Rhin Laryng"},{"key":"2025082804053098000_11.1.e226364.5","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.110109"},{"key":"2025082804053098000_11.1.e226364.6","unstructured":"Campana D , Pui CH . Chapter 96: Childhood leukemia. In: Niederhuber JE , Armitage JO , Dorshow JH , Kastan MB , Tepper JE . eds. Abeloff\u2019s Clinical Oncology. 5th edn. Philadelphia, PA: Elsevier, 2014."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bcr-2018-226364","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:05:38Z","timestamp":1756379138000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,28]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bcr-2018-226364"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226364","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}