{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:01:43Z","timestamp":1768870903047,"version":"3.49.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,8,29]]},"abstract":"<jats:p>We present two cases of culture-proven fungal keratitis on natamycin treatment which developed periocular erythema, oedema, burning sensation and pruritus within 48\u2009hours of the addition of topical voriconazole. On clinical examination, periocular erythema with induration was noted. A diagnosis of orbital cellulitis was suspected, but the absence of pain and tenderness refuted the diagnosis on clinical grounds. A dermatology consultation was sought, and a diagnosis of periocular contact dermatitis with voriconazole was made. A skin patch test was performed with the same medication; however, it was negative. Topical voriconazole therapy was withdrawn, and the patient was prescribed cold compresses and oral antihistamine medication, to which they responded well.<\/jats:p>","DOI":"10.1136\/bcr-2018-226498","type":"journal-article","created":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T21:25:47Z","timestamp":1537046747000},"page":"bcr-2018-226498","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Periocular contact dermatitis with use of topical voriconazole 1% in mycotic keratitis"],"prefix":"10.1136","volume":"2018","author":[{"given":"Pranita","family":"Sahay","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ibrahime","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prafulla Kumar","family":"Maharana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"2025082803270333000_2018.sep14_2.bcr-2018-226498.1","first-page":"241","article-title":"Voriconazole: the newest triazole antifungal 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