{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:38:18Z","timestamp":1777905498459,"version":"3.51.4"},"reference-count":8,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,3,27]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>A case of Hunter syndrome, 6\u00bd-year-old boy presented with persistent thrombocytopenia and bleeding diathesis. However, cytopenia is not a usual presentation in patients with mucopolysaccharidosis II. After ruling out other causes of severe thrombocytopenia, a clinical possibility of chronic Epstein-Barr virus (EBV) infection was considered. He was treated with intravenous immunoglobulin for refractory thrombocytopenia and intracranial bleed. This was followed by oral prednisolone. The EBV serology was found positive. Platelet counts gradually recovered and no recurrence of bleeds was observed. EBV infection usually causes haematological abnormalities, mainly atypical lymphocytosis, which is a feature of infectious mononucleosis, and uncomplicated cases often present with mild decreases in platelet counts. Severe thrombocytopenia is an extremely rare complication of acute or chronic EBV infection. In Asians, EBV infection should be considered in children presenting with thrombocytopenia, bleeding diathesis and anaemia along with organomegaly.<\/jats:p>","DOI":"10.1136\/bcr-2018-226518","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T12:15:11Z","timestamp":1555762511000},"page":"e226518","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Hunter syndrome with persistent thrombocytopenia"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7375-9892","authenticated-orcid":false,"given":"Inusha","family":"Panigrahi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, APC, PGIMER, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Dhanorkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, APC, PGIMER, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyaram","family":"Didel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, APC, PGIMER, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja Ashok","family":"Koganti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, APC, PGIMER, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,4,20]]},"reference":[{"key":"2025082623234498000_12.4.e226518.1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jped.2015.06.007","article-title":"Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge","volume":"92","author":"Bolis","year":"2016","journal-title":"J Pediatr"},{"issue":"Suppl 3","key":"2025082623234498000_12.4.e226518.2","first-page":"S216","article-title":"Acute disseminated encephalomyelitis and thrombocytopenia following Epstein-Barr virus infection","volume":"24","author":"Saeed","year":"2014","journal-title":"J Coll Physicians Surg Pak"},{"key":"2025082623234498000_12.4.e226518.3","doi-asserted-by":"publisher","DOI":"10.1086\/516114"},{"key":"2025082623234498000_12.4.e226518.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF03040424"},{"key":"2025082623234498000_12.4.e226518.5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00277-011-1248-6","article-title":"Hunter syndrome and new onset idiopathic thrombocytopenic purpura in a young patient","volume":"91","author":"Uz","year":"2012","journal-title":"Ann Hematol"},{"key":"2025082623234498000_12.4.e226518.6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ajh.2830380210","article-title":"Intravenous gammaglobulin treatment for immune thrombocytopenia associated with infectious mononucleosis","volume":"38","author":"Cyran","year":"1991","journal-title":"Am J Hematol"},{"key":"2025082623234498000_12.4.e226518.7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10545-017-0075-x","article-title":"Survival in idursulfase-treated and untreated patients with mucopolysaccharidosis type II: data from the Hunter Outcome Survey (HOS)","volume":"40","author":"Burton","year":"2017","journal-title":"J Inherit Metab Dis"},{"key":"2025082623234498000_12.4.e226518.8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.clim.2014.07.001","article-title":"NK and B cell deficiency in a MPS type II family with novel mutation in the IDS gene","volume":"154","author":"Torres","year":"2014","journal-title":"Clin Immunol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:23:53Z","timestamp":1756275833000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,20]]},"published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1136\/bcr-2018-226518"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226518","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}