{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:40:26Z","timestamp":1773733226018,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,10,9]]},"abstract":"<jats:p>A 6-year-old girl presented acutely with worsening frontal headaches. She had a 3-month history of lethargy, reduced appetite, weight loss, cough and intermittent fevers. A chest X-ray showed a left upper lobe consolidation, and a CT head showed multiple enhancing lesions with significant surrounding oedema in both cerebral hemispheres. Due to the strong suspicion of tuberculosis (TB), she was admitted and treated with anti-TB therapy and steroids. Following this, pulmonary infection with<jats:italic>Mycobacterium tuberculosis<\/jats:italic>was confirmed by a positive PCR from induced sputum. Cerebral spinal fluid (CSF) analysis was normal and tested negative for<jats:italic>M. tuberculosis<\/jats:italic>on PCR. During her first week of treatment, she developed polyuria, nocturia and polydipsia and was diagnosed with central diabetes insipidus. She was started on desmopressin which rapidly improved her symptoms, and she was continued on desmopressin for 3 months. Currently, she remains well and has shown a good response to TB treatment.<\/jats:p>","DOI":"10.1136\/bcr-2018-226590","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T15:09:21Z","timestamp":1542035361000},"page":"bcr-2018-226590","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cerebral tuberculomas in a 6-year-old girl causing central diabetes insipidus"],"prefix":"10.1136","volume":"2018","author":[{"given":"Shavindra","family":"Chellen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eisenhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Grandjean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.1","unstructured":"Public Health England. Tuberculosis in England: 2017. London: Public Health England, 2017."},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0967-5868(02)00285-0","article-title":"Diabetes insipidus in sellar-suprasellar tuberculoma","volume":"10","author":"Satyarthee","year":"2003","journal-title":"J Clin Neurosci"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.3","first-page":"314","article-title":"Suprasellar tuberculoma presenting with diabetes insipidus and hypothyroidism\u2013a case report","volume":"49","author":"Jain","year":"2001","journal-title":"Neurol India"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(00)00063-9"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.03.025"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.6","unstructured":"\u00a0World Health Organization. Global tuberculosis report 2017. Geneva: World Health Organization, 2017."},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.1.84"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.8","unstructured":"Marshall W , Bangert S . Clinical chemistry. Edinburgh: Mosby, 2008."},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.beem.2016.02.007","article-title":"Diabetes insipidus: Differential diagnosis and management","volume":"30","author":"Robertson","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.10","unstructured":"Imperial College Healthcare NHS Trust (2017). Anti-infective Guideline \u2013 First Line Drug choice for Children presenting with Specific Infectious Syndromes v6.0."},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11102-006-5420-2","article-title":"Suprasellar tubercular abscess presenting as panhypopituitarism: a common lesion in an uncommon site with a brief review of literature","volume":"9","author":"Dutta","year":"2006","journal-title":"Pituitary"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.12","unstructured":"Joint Committee on Vaccination and Immunisation (2011). Tuberculosis: the green book, chapter 32. https:\/\/www.gov.uk\/government\/publications\/tuberculosis-the-green-book-chapter-32"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit790"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.14","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.6.1092"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.15","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-rcpch.346"},{"key":"2025042706444102000_2018.nov12_1.bcr-2018-226590.16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.33.170.315"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-226590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:44:52Z","timestamp":1745761492000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-226590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":16,"alternative-id":["10.1136\/bcr-2018-226590"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-226590","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]}}}