{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:58:16Z","timestamp":1789095496924,"version":"build-2803163510"},"reference-count":45,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,12,20]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Somatostatinomas are rare neuroendocrine tumours, mostly located in the pancreas or duodenum, with an estimated incidence of 1 in 40 million. Duodenal somatostatinomas (DSs) are usually found in association with neurofibromatosis type 1 (NF1), tuberous sclerosis and Von Hippel-Lindau syndrome. Gastrointestinal stromal tumours (GIST) have also been described in NF1, but the association with somatostatinoma is very uncommon. We report the case of a patient with NF1 who presented with obstructive jaundice due to multiple firm nodules around the ampulla of Vater. A pancreaticoduodenectomy was performed and revealed a 1\u2009cm duodenal\/ampullary mass which stained positive for somatostatin, together with a GIST also found on the duodenal wall. Despite its rarity, ampullary somatostatinomas should be considered in the differential diagnosis of biliary tract dilation in patients with NF1.<\/jats:p>","DOI":"10.1136\/bcr-2018-226702","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T04:25:33Z","timestamp":1547180733000},"page":"bcr-2018-226702","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Duodenal somatostatinoma presenting as obstructive jaundice with the coexistence of a gastrointestinal stromal tumour in neurofibromatosis type 1: a case with review of the literature"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-1167","authenticated-orcid":false,"given":"Subhanudh","family":"Thavaraputta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Pathology, Texas Tech Univeristy Health Sciences Center, Lubbock, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Rivas Mejia","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Texas Tech University Health Science Center School of Medicine, Lubbock, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Lado-Abeal","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Texas Tech University Health Science Center School of Medicine, Lubbock, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"2025082801595920000_12.1.bcr-2018-226702.1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1056\/NEJM198112313052704","article-title":"Von Recklinghausen Neurofibromatosis","volume":"305","author":"Riccardi","year":"1981","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025082801595920000_12.1.bcr-2018-226702.2","unstructured":"Adil A , Singh AK . 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