{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:40:00Z","timestamp":1775184000006,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,8,21]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>We present a term neonate with severe sepsis, presenting on day 10 of life. The neonate presented with bilateral purulent eye discharge and hepatosplenomegaly. On investigation, persistent leucocytosis was observed and thus the possibility of leucocyte adhesion defect was considered. Flow cytometry confirmed the diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2018-227065","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T08:30:06Z","timestamp":1567153806000},"page":"e227065","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Leucocyte adhesion defect presenting as fulminant sepsis in a new born"],"prefix":"10.1136","volume":"12","author":[{"given":"Vishal","family":"Gupta","sequence":"first","affiliation":[{"name":"Neonatology, Neonest Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Pandita","sequence":"additional","affiliation":[{"name":"Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astha","family":"Panghal","sequence":"additional","affiliation":[{"name":"Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Pillai","sequence":"additional","affiliation":[{"name":"Division of Neonatology, BC Women\u2019s and Children\u2019s Hospital, Vancouver, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"2025082802061876000_12.8.e227065.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.07.005"},{"key":"2025082802061876000_12.8.e227065.2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1164\/rccm.201512-2454ED","article-title":"Leukocyte adhesion deficiency iv. monocyte integrin activation deficiency in cystic fibrosis","volume":"193","author":"Fan","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"2025082802061876000_12.8.e227065.3","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-012-0005-9"},{"key":"2025082802061876000_12.8.e227065.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06389.x"},{"key":"2025082802061876000_12.8.e227065.5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s12026-015-8706-5","article-title":"Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1","volume":"64","author":"Levy-Mendelovich","year":"2016","journal-title":"Immunol Res"},{"key":"2025082802061876000_12.8.e227065.6","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jaip.2017.12.008","article-title":"Leukocyte adhesion deficiency-I: a comprehensive review of all published cases","volume":"6","author":"Almarza Novoa","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2025082802061876000_12.8.e227065.7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12288-013-0286-8","article-title":"Hyperleukocytosis in newborn: a diagnosis of concern","volume":"30","author":"Parvez","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"key":"2025082802061876000_12.8.e227065.8","doi-asserted-by":"publisher","DOI":"10.1159\/000066968"},{"key":"2025082802061876000_12.8.e227065.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05438.x"},{"key":"2025082802061876000_12.8.e227065.10","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1931"},{"key":"2025082802061876000_12.8.e227065.11","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007141"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:06:23Z","timestamp":1756371983000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,30]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bcr-2018-227065"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227065","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}