{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:29:05Z","timestamp":1762867745730,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Small cell carcinoma (SmCC) of the vagina is a rare and aggressive tumour. It comprises only 1% \u20132% of all gynaecological malignancies 85% of the patients with SmCC vagina die within a year of diagnosis. Here we report the case of a 65-year-old woman with stage III primary neuroendocrine carcinoma of vagina who was treated with chemoradiotherapy. The patient survived 1 year and 10 months after the initial presentation. SmCC of the vagina is very rare and despite being aggressive, the local disease can be controlled with a chemoradiation regimen.<\/jats:p>","DOI":"10.1136\/bcr-2018-227100","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T11:45:11Z","timestamp":1552131911000},"page":"e227100","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Primary small cell carcinoma of the vagina: a rare instance of prolonged survival"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-1114","authenticated-orcid":false,"given":"Sri Harsha","family":"Kombathula","sequence":"first","affiliation":[{"name":"Radiation Oncology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragna Sagar","family":"Rapole","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyama Sudha","family":"Prem","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana","family":"Badhe","sequence":"additional","affiliation":[{"name":"Pathology, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,9]]},"reference":[{"key":"2025082800423817000_12.3.e227100.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/306921","article-title":"Primary small cell neuroendocrine carcinoma of vagina: a rare case report","volume":"2011","author":"Bhalodia","year":"2011","journal-title":"Patholog Res Int"},{"key":"2025082800423817000_12.3.e227100.2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.5858\/2004-128-857-PSCNCO","article-title":"Primary small cell neuroendocrine carcinoma of the vagina: a clinicopathologic study","volume":"128","author":"Bing","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"2025082800423817000_12.3.e227100.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.04.011"},{"key":"2025082800423817000_12.3.e227100.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000145724.40477.50"},{"key":"2025082800423817000_12.3.e227100.5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/CCO.0b013e3283565ed6","article-title":"The management of small-cell carcinomas of the gynecologic tract","volume":"24","author":"Cohen","year":"2012","journal-title":"Curr Opin Oncol"},{"key":"2025082800423817000_12.3.e227100.6","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000743"},{"key":"2025082800423817000_12.3.e227100.7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/827037","article-title":"Primary small cell carcinoma of the vagina","volume":"2013","author":"Oliveira","year":"2013","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082800423817000_12.3.e227100.8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.501"},{"key":"2025082800423817000_12.3.e227100.9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/827037","article-title":"Primary Small Cell Carcinoma of the Vagina","volume":"2013","author":"Oliveira","year":"2013","journal-title":"Case Rep Obstet Gynecol"},{"key":"2025082800423817000_12.3.e227100.10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2559.1992.tb00409.x","article-title":"Small cell (neuroendocrine) carcinoma of the vagina","volume":"21","author":"Miliauskas","year":"1992","journal-title":"Histopathology"},{"key":"2025082800423817000_12.3.e227100.11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.5858\/2004-128-857-PSCNCO","article-title":"Primary small cell neuroendocrine carcinoma of the vagina: a clinicopathologic study","volume":"128","author":"Bing","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"2025082800423817000_12.3.e227100.12","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000012116","article-title":"Primary small cell neuroendocrine carcinoma of the vagina. 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