{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:40:04Z","timestamp":1756327204755,"version":"3.44.0"},"reference-count":51,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,15]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>A middle-aged man presented with progressively worsening breathlessness and non-productive cough for the last 3 months. On examination, his breathing was stridulous and air entry was decreased bilaterally. He underwent emergency fibre-optic bronchoscopy, which revealed a tracheal growth causing luminal narrowing, and after tumour debulking, he improved symptomatically. Histopathological evaluation of the specimen revealed an adenoid cystic carcinoma of the trachea, and systemic evaluation revealed metastatic dissemination. Systemic molecular-targeted therapy was initiated (gefitinib and later imatinib mesylate) and continued for 5 years, in view of stable disease on periodic follow-up. He subsequently presented with breathlessness again, which was managed with an emergency tracheostomy. In view of stable systemic disease and local progression only, he received definitive radiotherapy with image-guided volumetric modulated arc therapy, which resulted in a complete radiological response. The patient has been disease-free for the last 9 months.<\/jats:p>","DOI":"10.1136\/bcr-2018-227128","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T06:45:12Z","timestamp":1553237112000},"page":"e227128","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Image-guided volumetric modulated arc therapy (IG-VMAT) for unresectable ACC of the trachea: a feasible curative option"],"prefix":"10.1136","volume":"12","author":[{"given":"Rahul Lal","family":"Chowdhary","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kundan Singh","family":"Chufal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali Kakria","family":"Pahuja","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manindra","family":"Bhushan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-6797","authenticated-orcid":false,"given":"Irfan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"2025082713192866000_12.3.e227128.1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9229-z"},{"key":"2025082713192866000_12.3.e227128.2","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3109\/00016489109100772","article-title":"Occurrence of tracheal carcinoma in Finland","volume":"111","author":"Manninen","year":"1991","journal-title":"Acta Otolaryngol"},{"key":"2025082713192866000_12.3.e227128.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00597-8"},{"key":"2025082713192866000_12.3.e227128.4","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.7.688"},{"key":"2025082713192866000_12.3.e227128.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.05.018"},{"key":"2025082713192866000_12.3.e227128.6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.3.803"},{"key":"2025082713192866000_12.3.e227128.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70011-9"},{"key":"2025082713192866000_12.3.e227128.8","unstructured":"Choi NC . 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