{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:42:26Z","timestamp":1788306146168,"version":"build-2803163510"},"reference-count":5,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,1,18]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2\u2009days, loss of appetite for 1\u2009month and progressive fatigability for the preceding 4\u2009months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison\u2019s disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.<\/jats:p>","DOI":"10.1136\/bcr-2018-227187","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T06:08:52Z","timestamp":1551247732000},"page":"e227187","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-4474","authenticated-orcid":false,"given":"Akhila","family":"Arya P V","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Government Medical College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Government Medical College, Kozhikode, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-4792","authenticated-orcid":false,"given":"Dileep","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-3246","authenticated-orcid":false,"given":"Rishi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"2025082713172192000_12.2.e227187.1","first-page":"212","article-title":"Eine biglandulare Erkrankung (Nebennieren und Schilddruse bei Morbus Addisonni)","volume":"21","author":"Schmidt","year":"1926","journal-title":"Dtsch Pathol Ges"},{"key":"2025082713172192000_12.2.e227187.2","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJMra1713301","article-title":"Autoimmune Polyendocrine Syndromes","volume":"378","author":"Husebye","year":"2018","journal-title":"N Engl J Med"},{"key":"2025082713172192000_12.2.e227187.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02561.x"},{"key":"2025082713172192000_12.2.e227187.4","first-page":"503","article-title":"A case of autoimmune polyglandular syndrome.ype 2 associated with atypical form of scleromyxedema","volume":"26","author":"Prylutskyi","year":"2016","journal-title":"Ethiop J Health Sci"},{"key":"2025082713172192000_12.2.e227187.5","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005062","article-title":"Delayed diagnosis with autoimmune polyglandular syndrome type 2 causing acute adrenal crisis: A case report","volume":"95","author":"Wang","year":"2016","journal-title":"Medicine"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:17:27Z","timestamp":1756325847000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,26]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/bcr-2018-227187"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227187","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}