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His head circumference at birth and 5 months was at 90th centile. He developed infantile spasm and electroencephalogram showed hypsarrhythmia at 5 months of age. Seizures were controlled. He is under evaluation for surgical treatment. Case 2: ACC with a midline cyst was reported in the midtrimester US scan of a male infant. Subsequent fetal scans showed increasing size of the cyst. At birth, he had macrocephaly with a head circumference above 97th centile. MRI of the brain confirmed ACC with IHC. The parents refused a cystoperitoneal shunt offered. The child displayed gross neurodevelopmental delay with progressive hydrocephalus on follow-up and succumbed to aspiration pneumonia at 22 months of age.<\/jats:p>","DOI":"10.1136\/bcr-2018-227366","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"bcr-2018-227366","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Agenesis of the corpus callosum with interhemispheric cyst: clinical implications and outcome"],"prefix":"10.1136","volume":"11","author":[{"given":"Krishna Gopagondanahalli","family":"Revanna","sequence":"first","affiliation":[{"name":"Neonatology, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Samuel","family":"Rajadurai","sequence":"additional","affiliation":[{"name":"Neonatology, KK Women\u2019s and Children\u2019s Hospital, Singapore"},{"name":"Duke NUS Medical School, Singapore"},{"name":"NUS Yong Loo Lin School of Medicine, Singapore"},{"name":"Lee Kong Chian School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Chandran","sequence":"additional","affiliation":[{"name":"Neonatology, KK Women\u2019s and Children\u2019s Hospital, Singapore"},{"name":"Duke NUS Medical School, Singapore"},{"name":"NUS Yong Loo Lin School of Medicine, Singapore"},{"name":"Lee Kong Chian School of Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"2025082706464829000_11.1.bcr-2018-227366.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039804"},{"key":"2025082706464829000_11.1.bcr-2018-227366.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2005.08.008"},{"key":"2025082706464829000_11.1.bcr-2018-227366.3","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.7863\/jum.2012.31.11.1811","article-title":"Asymmetric ventriculomegaly, interhemispheric cyst, and dysgenesis of the corpus callosum (AVID): an imaging triad","volume":"31","author":"Oh","year":"2012","journal-title":"J Ultrasound Med"},{"key":"2025082706464829000_11.1.bcr-2018-227366.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt358"},{"key":"2025082706464829000_11.1.bcr-2018-227366.5","first-page":"68","volume-title":"Handbook of clinical neurology","volume":"87","author":"Sarnat","year":"2008"},{"key":"2025082706464829000_11.1.bcr-2018-227366.6","unstructured":"Barkovich AJ . 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