{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:12Z","timestamp":1756339452045,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,1,22]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>We describe an unusual case of pre-B lymphoblastic leukaemia presenting with a unilateral maxillary sinus mass in which biopsies of the primary mass and the bone marrow demonstrated conflicting immunophenotyping results. The extramedullary mass was consistent with a precursor B-cell malignancy, while the bone marrow was initially reported as a possible mature B-cell malignancy. The treatments for the two are fundamentally different, which necessitated a delay in the initiation of his chemotherapy until a clear diagnosis was made. Mixed lineage leukaemia gene rearrangement was confirmed by fluorescence in situ hybridisation in both the primary mass and bone marrow, which unified the diagnosis as pre-B acute lymphoblastic leukaemia given the common cytogenetic feature.<\/jats:p>","DOI":"10.1136\/bcr-2018-227400","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T04:45:13Z","timestamp":1550292313000},"page":"e227400","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["<i>MLL<\/i> rearranged acute lymphoblastic leukaemia presenting as a maxillary sinus mass with a discordant immunophenotypic profile from the bone marrow"],"prefix":"10.1136","volume":"12","author":[{"given":"Yunzu Michele","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Qin","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-0057","authenticated-orcid":false,"given":"Dennis John","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology-Oncology, University of California San Diego, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2025082706570444000_12.2.e227400.1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61203"},{"key":"2025082706570444000_12.2.e227400.2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401148"},{"key":"2025082706570444000_12.2.e227400.3","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002904","article-title":"Burkitt-type acute lymphoblastic leukemia with precursor b-cell immunophenotype and partial tetrasomy of 1q: a case report","volume":"95","author":"Sato","year":"2016","journal-title":"Medicine"},{"key":"2025082706570444000_12.2.e227400.4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-0609.2007.00992.x","article-title":"Burkitt lymphoma\/leukaemia transformed from a precursor B cell: clinical and molecular aspects","volume":"80","author":"Hassan","year":"2008","journal-title":"Eur J Haematol"},{"key":"2025082706570444000_12.2.e227400.5","doi-asserted-by":"publisher","DOI":"10.1309\/LM0BOC84GSQGHYKD"},{"key":"2025082706570444000_12.2.e227400.6","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.5858\/2003-127-1340-IBALLW","article-title":"Is B-lineage acute lymphoblastic leukemia with a mature phenotype and l1 morphology a precursor B-lymphoblastic leukemia\/lymphoma or burkitt leukemia\/lymphoma?","volume":"127","author":"Li","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"2025082706570444000_12.2.e227400.7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1182\/blood.V77.3.440.440","article-title":"Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases","volume":"77","author":"Pui","year":"1991","journal-title":"Blood"},{"key":"2025082706570444000_12.2.e227400.8","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.3109\/10428194.2016.1141407","article-title":"B-cell acute lymphoblastic leukemia with mature phenotype and MLL rearrangement: report of five new cases and review of the literature","volume":"57","author":"Sajaroff","year":"2016","journal-title":"Leuk Lymphoma"},{"key":"2025082706570444000_12.2.e227400.9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2141.2011.08870.x","article-title":"Aberrant T-cell antigen expression in B lymphoblastic leukaemia","volume":"155","author":"Hussein","year":"2011","journal-title":"Br J Haematol"},{"key":"2025082706570444000_12.2.e227400.10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402708"},{"key":"2025082706570444000_12.2.e227400.11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5858\/arpa.2013-0674-RA","article-title":"Systematic review of the effectiveness of fine-needle aspiration and\/or core needle biopsy for subclassifying lymphoma","volume":"139","author":"Frederiksen","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"2025082706570444000_12.2.e227400.12","unstructured":"National Comprehensive Cancer Network. B-Cell lymphomas. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell.pdf (Accessed 30th Oct 2018)."},{"key":"2025082706570444000_12.2.e227400.13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/sj.leu.2404992","article-title":"Mature B-cell lymphoblastic leukemia with MLL rearrangement: an uncommon and distinct subset of childhood acute leukemia","volume":"22","author":"Blin","year":"2008","journal-title":"Leukemia"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:57:13Z","timestamp":1756303033000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,15]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/bcr-2018-227400"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227400","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}