{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:51:21Z","timestamp":1784605881355,"version":"3.55.0"},"reference-count":6,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,1]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Recreational use of nitrous oxide as a \u2018legal high\u2019 is increasing in the UK. Physicians should be \u2018street wise\u2019 to this increasing prevalence and aware of the potential neurological complications which may result from misuse. We describe a 17-year-old male patient who presented to neurology with a severe myelopathy following prolonged recreational use of nitrous oxide. MRI demonstrated characteristic changes affecting the dorsal columns and blood tests demonstrated a \u2018functional\u2019 B<jats:sub>12<\/jats:sub> deficiency. Clinical and radiological improvement was noted following initiation of vitamin B<jats:sub>12<\/jats:sub> replacement.<\/jats:p>","DOI":"10.1136\/bcr-2018-227439","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:55:40Z","timestamp":1550120140000},"page":"e227439","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Nitrous oxide myelopathy with functional vitamin B<sub>\n                     <sub>12<\/sub>\n                  <\/sub>deficiency"],"prefix":"10.1136","volume":"12","author":[{"given":"John","family":"Williamson","sequence":"first","affiliation":[{"name":"Department of Neurology, The Walton Centre Foundation NHS Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Huda","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Walton Centre Foundation NHS Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Damodaran","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Walton Centre Foundation NHS Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"2025082702361710000_12.2.e227439.1","unstructured":"Drug Misuse: Findings from the 2017\/2018 Crime Survey for England and Wales. UK Home Office. 2018 https:\/\/www.gov.uk\/government\/statistics\/drug-misuse-findings-from-the-2017-to-2018-csew"},{"key":"2025082702361710000_12.2.e227439.2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2014-001071"},{"key":"2025082702361710000_12.2.e227439.3","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116632375"},{"key":"2025082702361710000_12.2.e227439.4","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181870a17"},{"key":"2025082702361710000_12.2.e227439.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8801-3"},{"key":"2025082702361710000_12.2.e227439.6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5226"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:36:23Z","timestamp":1756287383000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,13]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/bcr-2018-227439"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227439","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}