{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:54:54Z","timestamp":1776862494698,"version":"3.51.2"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,2,28]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Hypereosinophilic syndromes are rare in children. Sporadic, mild-severity FIP1L1-platelet-derived growth factor receptor \u03b1 (PDGFR\u03b1) rearrangement cases have been reported, mainly in boys. We present the case of a 5-year-old girl referred from her African country of birth, due to severe constitutional symptoms, multifocal bone pain, headache, gastrointestinal complaints, cardiomyopathy and unexplained hypereosinophilia. She presented multiple end-organ diseases and striking bone involvement. Although she had a positive serology for <jats:italic>Strongyloides stercoralis<\/jats:italic>, extensive evaluation detected a FIP1L1-PDGFRA fusion gene. Systemic corticosteroids and low-dose imatinib were started and the child became asymptomatic. After 9 months of treatment, FIP1L1-PDGFRA was no longer detected.<\/jats:p>","DOI":"10.1136\/bcr-2018-227653","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T08:51:28Z","timestamp":1556527888000},"page":"e227653","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Hypereosinophilia and severe bone disease in an African child: an unexpected diagnosis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4776-1053","authenticated-orcid":false,"given":"Sofia","family":"Bota","sequence":"first","affiliation":[{"name":"Women, Child and Adolescents Department, Hospital Dona Estefania, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Alves","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Dona Estefania, Lisboa, 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