{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:10:02Z","timestamp":1756285802719,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>This is a case of a 67-year-old woman, known to have multiple medical problems, mainly papillary thyroid cancer status post-total thyroidectomy and cervical neck dissection in addition to radioactive iodine currently in remission for 1\u2009year, who presented to the hospital with severe weakness and fatigue. The initial workup showed significant hypercalcaemia and suppressed Parathyroid hormone (PTH). The patient was treated with hydration and pamidronate and her hypercalcaemia and symptoms improved. The differential was wide, however, a CT scan of the chest, abdomen and pelvis did show multiple liver and splenic nodular lesions; therefore, malignancy was the highest possible diagnosis. Biopsy of the splenic lesion confirmed the diagnosis of sarcoidosis. Therefore, the patient was diagnosed with primary isolated nodular hepatosplenic sarcoidosis mimicking malignancy and causing significant symptomatic hypercalcaemia.<\/jats:p>","DOI":"10.1136\/bcr-2018-227703","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T06:05:48Z","timestamp":1548223548000},"page":"e227703","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Primary isolated hepatosplenic sarcoidosis mimicking malignancy and causing symptomatic hypercalcaemia"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-7292","authenticated-orcid":false,"given":"Tarek","family":"Haykal","sequence":"first","affiliation":[{"name":"Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saira","family":"Sundus","sequence":"additional","affiliation":[{"name":"Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan","family":"Bachuwa","sequence":"additional","affiliation":[{"name":"Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Danish","sequence":"additional","affiliation":[{"name":"Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"2025082701374453000_12.1.e227703.1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4081\/reumatismo.2017.965","article-title":"Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota","volume":"69","author":"Ungprasert","year":"2017","journal-title":"Reumatismo"},{"key":"2025082701374453000_12.1.e227703.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2104046"},{"key":"2025082701374453000_12.1.e227703.3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/joim.12198","article-title":"Approaches to the treatment of some of the troublesome manifestations of sarcoidosis","volume":"275","author":"Eklund","year":"2014","journal-title":"J Intern Med"},{"key":"2025082701374453000_12.1.e227703.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2011.08.004"},{"key":"2025082701374453000_12.1.e227703.5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1100\/tsw.2010.36","article-title":"Localized hepatosplenic sarcoidosis with an elevated serum CA-125 level","volume":"10","author":"Herati","year":"2010","journal-title":"ScientificWorldJournal"},{"key":"2025082701374453000_12.1.e227703.6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/926203","article-title":"Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice","volume":"2014","author":"Tana","year":"2014","journal-title":"Biomed Res Int"},{"key":"2025082701374453000_12.1.e227703.7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000003089","article-title":"Life-threatening hypercalcemia revealing diffuse and isolated acute sarcoid-like myositis: a new entity? (a case-series)","volume":"95","author":"Mageau","year":"2016","journal-title":"Medicine"},{"key":"2025082701374453000_12.1.e227703.8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11657-017-0360-1","article-title":"Glucocorticoid sparing effect of zoledronic acid in sarcoid hypercalcemia","volume":"12","author":"Kuchay","year":"2017","journal-title":"Arch Osteoporos"},{"key":"2025082701374453000_12.1.e227703.9","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1002\/hep.28966","article-title":"Anti-TNF-\u03b1 for necrotizing sarcoid granulomatosis of the liver","volume":"65","author":"Sebode","year":"2017","journal-title":"Hepatology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:37:56Z","timestamp":1756283876000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,22]]},"published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1136\/bcr-2018-227703"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227703","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}