{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:58:04Z","timestamp":1769597884411,"version":"3.49.0"},"reference-count":9,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,12,12]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Beer is one of the most consumed alcoholic beverages worldwide but allergic reactions to this beverage are uncommon. The authors present a case report of a 32-year-old male patient, sent to our Allergy and Immunology Department due to anaphylaxis minutes after Franziskaner beer ingestion. He tolerates all other alcoholic beverages. Prick tests to cereals were positive to wheat, corn and barley, as well as to peach. Prick-to-prick tests were performed with nine beer brands, all positive. Immunoglobulin (Ig)E to Pru p 3 was 14.8 kU\/L. Sodium dodecyl sulfate polyacrylamide gel electrophoresis inhibition immunoblotting was performed with the Franziskaner beer extract in solid phase and both cereal extracts (wheat, barley and corn) and Pru p 3 as inhibitors. Extracts from wheat, barley and corn, and Pru p 3 purified protein were able to inhibit almost totally the IgE-binding to the Franziskaner beer extract. It seemed likely that the IgE-binding bands detected in the Franziskaner beer extract could be an LTP from cereals.<\/jats:p>","DOI":"10.1136\/bcr-2018-227723","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T05:15:26Z","timestamp":1546578926000},"page":"e227723","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Beer: an uncommon cause of anaphylaxis"],"prefix":"10.1136","volume":"12","author":[{"given":"Joana Sofia","family":"Pita","sequence":"first","affiliation":[{"name":"Allergy & Clinical Immunology Deparment, Coimbra Universitary Hospital Centre, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[{"name":"Allergy & Clinical Immunology Consult, Santo Andr\u00e9 Hospital, Leiria, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Bartolome","sequence":"additional","affiliation":[{"name":"Roxall. R&D Department, Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Allergy & Clinical Immunology Deparment, Coimbra Universitary Hospital Centre, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Todo","family":"Bom","sequence":"additional","affiliation":[{"name":"Allergy & Clinical Immunology Deparment, Coimbra Universitary Hospital Centre, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"2025082803165550000_12.1.e227723.1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1398-9995.2012.02872.x","article-title":"Allergy to beer in LTP-sensitized patients: beers are not all the same","volume":"67","author":"Quercia","year":"2012","journal-title":"Allergy"},{"key":"2025082803165550000_12.1.e227723.2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1067\/mai.2001.118793","article-title":"Isolation and characterization of barley lipid transfer protein and protein Z as beer allergens","volume":"108","author":"Garc\u00eda-Casado","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"2025082803165550000_12.1.e227723.3","first-page":"380","article-title":"Beer anaphylaxis","volume":"11","author":"Nusem","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"2025082803165550000_12.1.e227723.4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1081-1206(10)61436-6","article-title":"Anaphylaxis to wheat beer","volume":"92","author":"Herzinger","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025082803165550000_12.1.e227723.5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1034\/j.1398-9995.1999.00827.x","article-title":"Beer-induced anaphylaxis: identification of allergens","volume":"54","author":"Figueredo","year":"1999","journal-title":"Allergy"},{"issue":"5 Pt 1","key":"2025082803165550000_12.1.e227723.6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0091-6749(99)70449-5","article-title":"Beer anaphylaxis","volume":"103","author":"Fern\u00e1ndez-Anaya","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"2025082803165550000_12.1.e227723.7","first-page":"268","article-title":"Beer-induced anaphylaxis due to barley sensitization: two case reports","volume":"9","author":"Bonadonna","year":"1999","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2025082803165550000_12.1.e227723.8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1081-1206(10)62325-3","article-title":"A case of allergy to beer showing cross-reactivity between lipid transfer proteins","volume":"87","author":"Asero","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025082803165550000_12.1.e227723.9","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1021\/acs.jafc.5b00631","article-title":"Proteomics, peptidomics, and immunogenic potential of wheat beer (Weissbier)","volume":"63","author":"Picariello","year":"2015","journal-title":"J Agric Food Chem"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:17:02Z","timestamp":1756376222000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,3]]},"published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1136\/bcr-2018-227723"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227723","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}