{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:05:04Z","timestamp":1791932704349,"version":"4.3.4"},"reference-count":6,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,1,13]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200\u2009c\/mm<jats:sup>3<\/jats:sup>) and elevated IgE levels (7050 IU\/mL; normal: &lt;164\u2009IU\/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15.60\u2009U\/mL (normal: &lt;12.01\u2009U\/mL). He responded to therapy with corticosteroids and voriconazole and was able to resume pembrolizumab thereafter with good clinical response.<\/jats:p>","DOI":"10.1136\/bcr-2018-227814","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:58:06Z","timestamp":1550120286000},"page":"e227814","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-6769","authenticated-orcid":false,"given":"Anthony A","family":"Donato","sequence":"first","affiliation":[{"name":"Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Krol","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"2025082713055573000_12.2.e227814.1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx286"},{"key":"2025082713055573000_12.2.e227814.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160221","article-title":"Adverse events associated with immune checkpoint blockade in patients with cancer: a systematic review of case reports","volume":"11","author":"Abdel-Wahab","year":"2016","journal-title":"PLoS One"},{"key":"2025082713055573000_12.2.e227814.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02458.x"},{"key":"2025082713055573000_12.2.e227814.4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1200\/JCO.2016.68.2005","article-title":"Pneumonitis in patients treated with anti-programmed death-1\/programmed death ligand 1 therapy","volume":"35","author":"Naidoo","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025082713055573000_12.2.e227814.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.04.012"},{"key":"2025082713055573000_12.2.e227814.6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/jof2020017","article-title":"Allergic Bronchopulmonary Aspergillosis","volume":"2","author":"Tracy","year":"2016","journal-title":"J Fungi"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:06:04Z","timestamp":1756325164000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,13]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/bcr-2018-227814"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227814","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}