{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:16:37Z","timestamp":1756383397625,"version":"3.44.0"},"reference-count":4,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,3,3]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>The Good\u2019s syndrome (GS) is a low prevalence entity where thymoma often is associated with immunodeficiency. Patients may start presenting recurrent rhinosinusal infections, bronchopulmonary infections, haematological alterations and diarrhoea, secondary to immunodeficiency. They can also present respiratory symptoms and parathymic syndromes derived from the existence of thymoma, a slow-growing neoplasm located in the anterior mediastinum. We present the case of a 76-year-old man diagnosed with thymoma by image analysis, which had presented multiple episodes of pneumonia and two admissions to the hospital for diarrhoea of weeks of evolution. After finishing the study, the patient is diagnosed of GS. In this case, thymectomy prevented the appearance of parathymic syndrome, but without any effect on immunodeficiency symptoms. To decrease repeat infections, substitution therapy with immunoglobulins was started. The prognosis will depend mainly on the recurrent infectious and to a lesser extent on the thymic neoplasm.<\/jats:p>","DOI":"10.1136\/bcr-2018-227970","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T05:16:56Z","timestamp":1553145416000},"page":"e227970","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Immunodeficiency associated with tumour pathology: Good\u2019s syndrome"],"prefix":"10.1136","volume":"12","author":[{"given":"Javier","family":"Barrios Recio","sequence":"first","affiliation":[{"name":"Department of Allergy, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Perez Rodriguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-8262","authenticated-orcid":false,"given":"Ariel","family":"Callero","sequence":"additional","affiliation":[{"name":"Department of Allergy, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Martinez Tadeo","sequence":"additional","affiliation":[{"name":"Department of Allergy, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"2025082804285936000_12.3.e227970.1","first-page":"56","article-title":"Case report and literature review on Good\u2019s syndrome, a form of acquired immunodeficiency associated with thymomas","volume":"72","author":"Joven","year":"2013","journal-title":"Hawaii J Med Public Health"},{"key":"2025082804285936000_12.3.e227970.2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s40121-014-0045-7","article-title":"A bad case of good\u2019s syndrome","volume":"3","author":"Tachdjian","year":"2014","journal-title":"Infect Dis Ther"},{"key":"2025082804285936000_12.3.e227970.3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.clim.2014.04.002","article-title":"BAFF-R mutations in good\u2019s syndrome","volume":"153","author":"Lougaris","year":"2014","journal-title":"Clin Immunol"},{"key":"2025082804285936000_12.3.e227970.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60695-3"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2018-227970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:29:09Z","timestamp":1756380549000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2018-227970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":4,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,20]]},"published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1136\/bcr-2018-227970"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2018-227970","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}