{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:33:23Z","timestamp":1775759603305,"version":"3.50.1"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2019,12,20]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>This case report is the first case to our knowledge of intratendinous or peritendinous calcification reported in Gitelman syndrome (GS) patients. GS represents the clinical manifestations of inactivation of the <jats:italic>Slc12a3<\/jats:italic> genes encoding the thiazide-sensitive sodium chloride cotransporter and the <jats:italic>Trpm6-Mg<\/jats:italic> genes encoding the magnesium transporters in the distal convoluted tubule. Hence, the biochemical findings resemble those with thiazide diuretics such as hypokalaemia, hypomagnesaemia, hypocalciuria, metabolic alkalosis and low normal blood pressure. Serum calcium and phosphate levels are usually unaffected in GS unless associated with hyperparathyroidism or other hypercalcaemic aetiologies. We report a 69-year-old male patient with a history of GS who presented with bilateral ischial tuberosity tenderness. Further investigations confirmed the calcification of bilateral hamstring origin. Chondrocalcinosis is a known association of GS; however, extra-articular calcification is rare. Literature review illustrates sclerochoroidal calcification as the only reported soft tissue calcification apart from chondrocalcinosis.<\/jats:p>","DOI":"10.1136\/bcr-2018-227992","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T03:55:12Z","timestamp":1578455712000},"page":"e227992","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral hamstring origin calcification: rare presentation of Gitelman syndrome"],"prefix":"10.1136","volume":"13","author":[{"given":"Rahul","family":"Mohan","sequence":"first","affiliation":[{"name":"Trauma and Orthopaedics, St Helens and Knowsley NHS Trust, Prescot, Merseyside, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish Vinayakrao","family":"Dhotare","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, St Helens and Knowsley NHS Trust, Prescot, Merseyside, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Nithin","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Jakaraddi","sequence":"additional","affiliation":[{"name":"Trauma and Orthopaedics, St Helens and Knowsley NHS Trust, Prescot, Merseyside, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"2025082708200122000_13.1.e227992.1","first-page":"1","article-title":"Gitelman syndrome and primary hyperparathyroidism\u202f: a rare association","volume":"2018","author":"Rego","year":"2018","journal-title":"Case Reports"},{"key":"2025082708200122000_13.1.e227992.2","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-212375","article-title":"Management of a severe case of Gitelman syndrome with poor response to standard treatment","volume":"2016","author":"Koudsi","year":"2016","journal-title":"BMJ Case Rep"},{"key":"2025082708200122000_13.1.e227992.3","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3109\/0886022X.2013.824380","article-title":"Gitelman's syndrome associated with chondrocalcinosis: a case report","volume":"35","author":"Ko\u00e7kara","year":"2013","journal-title":"Ren Fail"},{"key":"2025082708200122000_13.1.e227992.4","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.027300"},{"key":"2025082708200122000_13.1.e227992.5","doi-asserted-by":"crossref","unstructured":"Lempainen L , Johansson K , Banke IJ , et al . 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