{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:09:43Z","timestamp":1758636583243,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,12,26]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Peripapillary choroidal neovascularisation (PPCNV) associated with optic disc drusen is a rare complication that can result in severe vision impairment in children. We report the first case of paediatric PPCNV secondary to optic disc drusen successfully treated with intravitreal aflibercept. A 6-year-old girl presented with a one week history of reduced vision in her right eye with best-corrected visual acuity of 20\/500. Fundus examination revealed bilateral elevated discs with a peripapillary pigmentary lesion in the right eye. Optical coherence tomography of the right eye showed marked subfoveal fluid. Both B-scan ultrasonography and fundus autofluorescence demonstrated findings consistent with optic disc drusen. Diagnosis of PPCNV was further confirmed on fluorescein fundus angiography. The child received three intravitreal aflibercept injections with complete resolution of the subfoveal fluid. Her visual acuity improved to 20\/25 with no recurrence at a 16-month follow-up. No adverse side effects were reported.<\/jats:p>","DOI":"10.1136\/bcr-2018-228134","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T13:00:51Z","timestamp":1547470851000},"page":"bcr-2018-228134","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Paediatric case of peripapillary choroidal neovascularisation associated with optic disc drusen treated with aflibercept"],"prefix":"10.1136","volume":"12","author":[{"given":"Weh Loong","family":"Gan","sequence":"first","affiliation":[{"name":"The University of Leeds, Leeds, UK"},{"name":"Ophthalmology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon W","family":"Long","sequence":"additional","affiliation":[{"name":"The University of Leeds, Leeds, UK"},{"name":"Ophthalmology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"2025082707061383000_12.1.bcr-2018-228134.1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.124586"},{"key":"2025082707061383000_12.1.bcr-2018-228134.2","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/j.jfo.2015.01.026","article-title":"Five-year follow-up of bilateral choroidal neovascularization secondary to optic nerve head drusen treated with ranibizumab in a nine-year-old girl","volume":"39","author":"Benouaich","year":"2016","journal-title":"J Fr Ophtalmol"},{"key":"2025082707061383000_12.1.bcr-2018-228134.3","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-204456"},{"key":"2025082707061383000_12.1.bcr-2018-228134.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-012-2180-8"},{"key":"2025082707061383000_12.1.bcr-2018-228134.5","first-page":"230","article-title":"Unilateral extrafoveal choroidal\u00a0eovascularization in a 13-year-old child with bilateral optic nerve drusen","volume":"115","author":"Jedrzejczak-Str\u00f3zniak","year":"2013","journal-title":"Klin Oczna"},{"key":"2025082707061383000_12.1.bcr-2018-228134.6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2147\/OPTH.S22991","article-title":"Bilateral choroidal neovascularization associated with optic nerve head drusen treated by antivascular endothelial growth factor therapy","volume":"6","author":"Delas","year":"2012","journal-title":"Clin Ophthalmol"},{"key":"2025082707061383000_12.1.bcr-2018-228134.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.10.011"},{"key":"2025082707061383000_12.1.bcr-2018-228134.8","doi-asserted-by":"crossref","unstructured":"Gregory-Evans K , Rai P , Patterson J . 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